Chang Y N, Xu H M
Department of Infectious Disease, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Infection and Immunity, Chongqing 400014, China.
Zhonghua Gan Zang Bing Za Zhi. 2021 Jan 20;29(1):16-20. doi: 10.3760/cma.j.cn501113-20201229-00684.
Hepatitis B and C virus infections are major global public health problem and economic burden. Most children with vertical infection have asymptomatic hepatitis, but the risk of chronic viral hepatitis and further development of liver cirrhosis or hepatocellular carcinoma is higher. Over the past two to three decades, with the rapid development of detection technology and the continuous research and development of antiviral drugs, great progress has been made in the diagnosis and treatment of viral hepatitis caused by hepatitis B and C infection. However, due to the particularity of its characteristics, it is still necessary to carefully judge and evaluate the diagnosis and antiviral treatment of children. This article focuses on the difficulties in the diagnosis and treatment of viral hepatitis in children, and summarizes its progress.
乙型和丙型肝炎病毒感染是全球主要的公共卫生问题和经济负担。大多数垂直感染的儿童患有无症状性肝炎,但慢性病毒性肝炎以及进一步发展为肝硬化或肝细胞癌的风险更高。在过去的二三十年里,随着检测技术的快速发展以及抗病毒药物的不断研发,乙型和丙型肝炎感染所致病毒性肝炎的诊断和治疗取得了巨大进展。然而,由于其特点的特殊性,对于儿童的诊断和抗病毒治疗仍需仔细判断和评估。本文重点关注儿童病毒性肝炎诊断和治疗中的难点,并总结其进展。