接受药物治疗联合/不联合部分囊切除术的犬移行细胞癌的临床转归。

Clinical outcomes of dogs with transitional cell carcinoma receiving medical therapy, with and without partial cystectomy.

机构信息

Hope Veterinary Specialists, Surgery Department, 40 Three Tun Road, Malvern, Pennsylvania 19355, USA (Bradbury, Mullin, May, Clifford); Koret School of Veterinary Medicine, The Hebrew University in Jerusalem, Yehoshua Hankin St 21, Rehovot 76100, Israel (Gillian); The Animal Medical Center, Interventional Radiology and Endoscopy, 510 East 62nd Street, New York, New York 10065, USA (Weisse); Katonah Bedford Veterinary Center, Medical Oncology Department, 546 Bedford Road, Bedford Hills, New York 10507, USA (Bergman); Red Bank Veterinary Hospital, Medical Oncology Department, 197 Hance Avenue, Tinton Falls, New Jersey 07724, USA (Morges); Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, Wisconsin 53706, USA (Vail).

出版信息

Can Vet J. 2021 Feb;62(2):133-140.

PMID:33542551

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7808205/

Abstract

The objective of this retrospective study was to evaluate the effects of surgery on outcome for dogs with naturally occurring urinary bladder transitional cell carcinoma. Forty-seven dogs met the inclusion criteria. Thirty-one dogs (Group A) were treated with partial cystectomy and adjunctive medical therapy and 16 dogs (Group B) were treated with medical therapy alone. Overall survival was greater in dogs treated with partial cystectomy and adjunctive medical therapy (498 days for Group A 335 days for Group B, hazard ratio 2.5; 95% confidence interval: 1.1 to 5.7; = 0.026). Progression-free survival was not different between groups (85 days for Group A 83 days for Group B; = 0.663). No prognostic factors were identified for progression-free survival. Due to the many cases in Group A that were lost to follow-up, time-to-event survival analysis was performed. No significant difference in overall survival was noted, and no prognostic factors were identified in the time-to-event analysis. Prospective, randomized studies are needed to determine the role of partial cystectomy in the treatment of transitional cell carcinoma.

摘要

本回顾性研究的目的是评估手术对自然发生的犬膀胱移行细胞癌的疗效。47 只狗符合纳入标准。31 只狗（A 组）接受部分膀胱切除术和辅助药物治疗，16 只狗（B 组）仅接受药物治疗。接受部分膀胱切除术和辅助药物治疗的犬的总生存时间更长（A 组为 498 天，B 组为 335 天，风险比为 2.5；95%置信区间：1.1 至 5.7；P=0.026）。两组之间的无进展生存时间无差异（A 组为 85 天，B 组为 83 天；P=0.663）。未确定无进展生存的预后因素。由于 A 组中有许多病例失访，因此进行了时间事件生存分析。总生存时间无显著差异，时间事件分析中也未确定预后因素。需要进行前瞻性、随机研究来确定部分膀胱切除术在治疗移行细胞癌中的作用。