Erkinjuntti T, Larsen T, Sulkava R, Ketonen L, Laaksonen R, Palo J
Department of Neurology, University of Helsinki, Finland.
Acta Neurol Scand. 1988 Jan;77(1):36-43. doi: 10.1111/j.1600-0404.1988.tb06971.x.
Demented patients with Alzheimer's disease (AD) (n = 67), multi-infarct dementia (MID) (n = 77) and probable vascular dementia (PVD) (n = 45) were studied with electroencephalography (EEG). All patients underwent a routine EEG examination and quantitative EEG was recorded from 14 patients with AD, 20 with MID, and 12 with PVD. The patient groups did not differ in regard to sex, age, education, or degree of dementia. Diffuse abnormality of EEG increased in AD, while driving response to photic stimulation and the mean frequency of background activity decreased in all groups with increasing degree of dementia. In quantitative EEG, the percentage of alpha power decreased and those of theta and delta power increased relative to the degree of dementia. Focal abnormalities, and irritative (spikes and/or sharp waves) and slow wave paroxysms were more common in MID than in AD. Patients with different types of dementia did not differ significantly in regard to diffuse abnormality, occurrence of driving response, mean background frequency, or parameters of quantitative EEG. The mean frequency of background activity and the degree of diffuse abnormality correlated with central and cortical atrophy, white matter low attenuation seen on computed tomography, and with neuropsychological findings.
对患有阿尔茨海默病（AD）（n = 67）、多发梗死性痴呆（MID）（n = 77）和可能的血管性痴呆（PVD）（n = 45）的痴呆患者进行了脑电图（EEG）研究。所有患者均接受了常规脑电图检查，并对14例AD患者、20例MID患者和12例PVD患者进行了定量脑电图记录。患者组在性别、年龄、教育程度或痴呆程度方面无差异。AD患者脑电图的弥漫性异常增加，而随着痴呆程度的增加，所有组对光刺激的驱动反应和背景活动的平均频率均降低。在定量脑电图中，相对于痴呆程度，α波功率百分比降低，θ波和δ波功率百分比增加。局灶性异常、刺激性（棘波和/或尖波）和慢波阵发在MID中比在AD中更常见。不同类型痴呆患者在弥漫性异常、驱动反应的发生、平均背景频率或定量脑电图参数方面无显著差异。背景活动的平均频率和弥漫性异常程度与中央和皮质萎缩、计算机断层扫描上可见的白质低衰减以及神经心理学结果相关。
