Djindjian M, Caron J P, Athayde A A, Février M J
Department of Neurosurgery, Hôpital Henri Mondor, Créteil, France.
Acta Neurochir (Wien). 1988;90(3-4):121-3. doi: 10.1007/BF01560565.
The decision to operate on a patient older than 70 years for an intracranial meningioma is always difficult. Therefore a series of meningiomas treated surgically in 30 cases older than 70 years has been reconsidered and studied according to the following parameters: Karnofsky's rating scale, physiological status of the patient (A.S.A. criteria), perifocal oedema and mass effect. The locations of the meningiomas were: convexity 13, parasagittal 6, falx 2, pterion (sphenoid ridge) 5, orbito-cranial 3, jugum sphenoidale 1, tentorium (occipital) 1. Postoperative survival at day 30 shows a mortality rate of 23% which increases to 37% at day 90 including causes like decubitus ulcers and 3 cases of fatal pulmonary embolism. In a comparable series of 31 cases from 60 to 70 years, mortality rate was only 16% at day 90. Two parameters seem essential for quantifying surgical risk: clinical status, oedema and mass effect, evaluated by CT scan. The best conditions seem combined when Karnofsky rating scale is higher than or equal to 50 with no or only limited perifocal hypodensity and without mass effect. Although meningiomas may remain dormant for many years or can be kept under control medically for some time, their development is unpredictable. We think therefore that a reasonable surgical risk can be taken on patients with good physical status and favourable parameters at the time of diagnosis, particularly if the meningioma is located at the convexity where the risk of recurrence is minimal. On the other hand, patients with unfavourable parameters are not recommended for surgery.
对于70岁以上的颅内脑膜瘤患者,决定是否进行手术总是很困难。因此,我们根据以下参数重新审视并研究了30例70岁以上接受手术治疗的脑膜瘤病例:卡诺夫斯基评分量表、患者的生理状态(美国麻醉医师协会标准)、瘤周水肿和占位效应。脑膜瘤的位置分别为:凸面13例、矢状窦旁6例、大脑镰2例、翼点(蝶骨嵴)5例、眶颅3例、蝶骨平台1例、小脑幕(枕部)1例。术后30天的生存率显示死亡率为23%,到90天时升至37%,死因包括褥疮和3例致命的肺栓塞。在一个由60至70岁患者组成的31例可比系列病例中,90天时的死亡率仅为16%。有两个参数似乎对量化手术风险至关重要:通过CT扫描评估的临床状态、水肿和占位效应。当卡诺夫斯基评分量表高于或等于50,且无或仅有有限的瘤周低密度影且无占位效应时,似乎具备了最佳条件。尽管脑膜瘤可能多年保持静止状态,或者在一段时间内可以通过药物控制,但它们的发展是不可预测的。因此,我们认为对于诊断时身体状况良好且参数有利的患者,可以承担合理的手术风险,特别是如果脑膜瘤位于凸面,复发风险最小。另一方面,不建议参数不利的患者进行手术。