Bassingthwaighte J B
Prog Cardiovasc Dis. 1977 Nov-Dec;20(3):165-89. doi: 10.1016/0033-0620(77)90019-6.
The time course of washout of tracer from the myocardium provides an estimate of the flow per unit volume when the blood-tissue exchange is flow-limited. Methods of testing for the flow-limitation and for the absence of influences of low permeability or diffusion on the washout include the uses of paired or multiple tracers and the examination for similarity of the shapes of the residue function or washout curves at varied coronary blood flows. A conceptual framework for these studies is provided by a clearance-flow diagram for the myocardium where capillaries are long compared to radial intercapillary distances. This anatomic-physiologic framework coupled with a probabilistic, general analytic approach and with various experimental approaches to tracer studies of mass transport through the heart provides a general basis for methods of estimating myocardial blood flow in the whole organ and in its component regions.
当血液与组织的交换受血流限制时，示踪剂从心肌中清除的时间过程可提供单位体积血流量的估计值。检测血流限制以及低渗透性或扩散对清除过程无影响的方法包括使用成对或多种示踪剂，以及在不同冠状动脉血流量下检查残留函数或清除曲线形状的相似性。心肌清除-血流图为这些研究提供了一个概念框架，在该图中，毛细血管的长度相对于毛细血管间的径向距离较长。这种解剖-生理框架，再加上概率性的通用分析方法以及各种用于心脏质量传输示踪剂研究的实验方法，为估计整个器官及其组成区域的心肌血流量的方法提供了总体基础。
