用放射性示踪剂估计血流量。
Estimation of blood flow with radioactive tracers.
作者信息
Bassingthwaighte J B, Holloway G A
出版信息
Semin Nucl Med. 1976 Apr;6(2):141-61. doi: 10.1016/s0001-2998(76)80002-5.
Abstract
The techniques of tracer dilution in the circulation, and of tracer uptake by and washout from an orgen, may be described using expressions that are general and are not dependent on specific models such as exponentials. The expressions have been applied to the measurement of cardiac output using impulse and constant rate injection techniques. Further expressions have been given for estimating organ blood flow from inflow/outflow concentration-time curves, and from the distribution of deposited tracer. Some problems with respect to the use of deposition techniques as they are ordinarily applied to the estimation of regional blood flow must be considered, particularly when there are capillary beds in series or where there is countercurrent diffusional shunting of diffusible tracers between inflow and outflow. This review deals with these various aspects of tracer theory as they relate to the measurement of blood flow.
摘要
循环中示踪剂稀释技术以及示踪剂被器官摄取和从器官洗脱的技术，可以用通用表达式来描述，这些表达式不依赖于诸如指数函数等特定模型。这些表达式已应用于使用脉冲注射和恒速注射技术测量心输出量。还给出了用于从流入/流出浓度-时间曲线以及沉积示踪剂的分布来估计器官血流量的进一步表达式。必须考虑将沉积技术通常应用于估计局部血流量时存在的一些问题，特别是当存在串联的毛细血管床或存在可扩散示踪剂在流入和流出之间的逆流扩散分流时。本综述涉及示踪剂理论与血流量测量相关的这些不同方面。
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