钙和磷稳态中的年龄依赖性性别差异。

Age-dependent sex differences in calcium and phosphate homeostasis.

作者信息

Koek W N H, Campos-Obando N, van der Eerden B C J, de Rijke Y B, Ikram M A, Uitterlinden A G, van Leeuwen J P T M, Zillikens M C

机构信息

Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.

Department of Clinical Chemistry, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.

出版信息

Endocr Connect. 2021 Mar;10(3):273-282. doi: 10.1530/EC-20-0509.

DOI:10.1530/EC-20-0509

PMID:33543729

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8052581/

Abstract

BACKGROUND

Sex differences in calcium and phosphate have been observed. We aimed to assess a relation with age.

METHODS

We used the laboratory values of serum calcium, phosphate and albumin from three different samples ( 2005, 2010 and 2014 years) using the hospital information system of Erasmus MC, Rotterdam. The samples were divided into three age groups: 1-17, 18-44 and ≥45 years. Sex differences in calcium and phosphate were analyzed using ANCOVA, adjusting for age and serum albumin. Furthermore, sex by age interactions were determined and we analyzed differences between age groups stratified by sex.

RESULTS

In all three samples there was a significant sex × age interaction for serum calcium and phosphate, whose levels were significantly higher in women compared to men above 45 years. No sex differences in the younger age groups were found. In men, serum calcium and phosphate levels were highest in the youngest age group compared to age groups of 18-44 and ≥45 years. In women, serum calcium levels were significantly higher in the age group 1-17 and the age group ≥45 years compared to the 18-44 years age group. In women, serum phosphate was different between the three different age groups with highest level in the group 1-17 years and lowest in the group 18-44 years.

CONCLUSION

There are age- dependent sex differences in serum calcium and phosphate. Furthermore, we found differences in serum calcium and phosphate between different age groups. Underlying mechanisms for these age- and sex- differences are not yet fully elucidated.

摘要

背景

已观察到钙和磷存在性别差异。我们旨在评估其与年龄的关系。

方法

我们使用鹿特丹伊拉斯姆斯医学中心医院信息系统中三个不同样本（2005年、2010年和2014年）的血清钙、磷和白蛋白实验室值。样本分为三个年龄组：1 - 17岁、18 - 44岁和≥45岁。使用协方差分析（ANCOVA）分析钙和磷的性别差异，并对年龄和血清白蛋白进行校正。此外，确定性别与年龄的交互作用，并分析按性别分层的年龄组之间的差异。

结果

在所有三个样本中，血清钙和磷均存在显著的性别×年龄交互作用，45岁以上女性的钙和磷水平显著高于男性。在较年轻的年龄组中未发现性别差异。在男性中，与18 - 44岁和≥45岁年龄组相比，最年轻年龄组的血清钙和磷水平最高。在女性中，1 - 17岁年龄组和≥45岁年龄组的血清钙水平显著高于18 - 44岁年龄组。在女性中，三个不同年龄组的血清磷存在差异，1 - 17岁组最高，18 - 44岁组最低。