Department of Cell and Molecular Biology, Department of Microbiology, Victor Babeş University of Medicine and Pharmacy, Timişoara, Romania;
Rom J Morphol Embryol. 2020 Apr-Jun;61(2):563-567. doi: 10.47162/RJME.61.2.28.
This paper presents the case of a 58-year-old heavy smoker female who came to our clinic with acute pain, as well as mastication and feeding difficulties. The macroscopic examination revealed oral erosive lesions and ulcerations. The polymorphic aspect of the lesions required the differential diagnosis of oral erythroplakia or carcinoma, which were excluded by biopsy. At the same time, we assessed the expression of S100 protein, Ki67 and the cluster of differentiation (CD) 4, CD8 (T-cell) and CD20 (B-cell) immune cell markers by immunohistochemical analysis. As a result, after the clinical and pathological assessment, the diagnosis of oral lichen planus was established, and a therapy plan was conducted. We observed a favorable clinical evolution after the administration of corticosteroids and immunomodulatory agents.
本文报告了一例 58 岁的重度吸烟女性患者，因急性疼痛以及咀嚼和进食困难就诊于我们的诊所。宏观检查显示口腔有糜烂性病变和溃疡。病变的多形性需要进行口腔红斑或癌的鉴别诊断，活检排除了这两种情况。同时，我们通过免疫组织化学分析评估了 S100 蛋白、Ki67 以及 CD4、CD8（T 细胞）和 CD20（B 细胞）免疫细胞标志物的表达。因此，经过临床和病理评估，诊断为口腔扁平苔藓，并制定了治疗方案。在给予皮质类固醇和免疫调节剂后，我们观察到了良好的临床转归。
