Kim C W, Kim Y I
Department of Pathology, College of Medicine, Seoul National University, Korea.
Am J Clin Pathol. 1988 Apr;89(4):481-7. doi: 10.1093/ajcp/89.4.481.
In order to further clarify the histologic criteria and prognostic measurement of appendiceal adenoma and well differentiated adenocarcinoma, lectin binding activity in 31 cases of appendiceal mucocele (6 hyperplasias, 16 adenomas and 9 adenocarcinomas) was studied using an immunoperoxidase staining method. An additional 45 cases of colonic lesions (15 adenomas and 30 adenocarcinomas) were also examined as the corresponding controls. Arachis hypogaea agglutinin (PNA) bound selectively to the neoplastic cells of adenocarcinomas in the appendix and colon, but in contrast, Dolichos biflorus agglutinin (DBA) binding activity was observed in both normal mucosa and adenomas, and in appendiceal hyperplasia. The fact that one case each of appendiceal adenoma and colonic villous adenoma showed a diffuse positive reactivity with PNA, which was comparable with similar binding in the adenocarcinoma cases, may suggest development of a malignant behavior prior to the histologic expression of malignant transformation in the appendiceal mucocele.
为了进一步阐明阑尾腺瘤和高分化腺癌的组织学标准及预后评估，采用免疫过氧化物酶染色法研究了31例阑尾黏液囊肿（6例增生、16例腺瘤和9例腺癌）的凝集素结合活性。另外选取45例结肠病变（15例腺瘤和30例腺癌）作为相应对照进行检测。花生凝集素（PNA）选择性地结合阑尾和结肠腺癌的肿瘤细胞，但与之相反，在正常黏膜、腺瘤以及阑尾增生中均观察到双花扁豆凝集素（DBA）的结合活性。1例阑尾腺瘤和1例结肠绒毛状腺瘤均显示与PNA呈弥漫性阳性反应，这与腺癌病例中的类似结合情况相当，这可能表明在阑尾黏液囊肿发生恶性转化的组织学表现之前就已出现恶性行为。
