Scientific Initiation Program, Sao Francisco University Medical School, Braganca Paulista, Sao Paulo, Brazil.
Postgraduated Program in Health, Sao Francisco University Medical School, Braganca Paulista, Sao Paulo, Brazil.
CNS Neurol Disord Drug Targets. 2018 Apr 26;17(1):34-42. doi: 10.2174/1871527317666171221110139.
This paper was based on a literature search of PubMed and Scielo databases using the keywords "Flavonoids, Neuroprotection, Quercetin, Rutin, Isoquercitrin, Alzheimer, Parkinson, Huntington" and combinations of all the words.
We collected relevant publications, during the period of 2000 to 2016, emphasizing in vivo and in vitro studies with neurological assessment of flavonol's potentials, as well as classifying studies according to evidence levels, in order to elucidate evidence-based literature and its application on clinical research. In addition, we highlight the importance of flavonols in modern research fields, indicating their neuroprotective potential and use thereof as preventive and therapeutic treatment of numerous neurodegenerative disease. Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and Huntington's disease, represent worldwide a major health problem with great financial impact. They are multifactorial diseases, hallmarked by similar pathogenesis that covers conditions such as oxidative stress, formation of free radicals, abnormal protein dynamics (degradation and aggregation), mitochondrial dysfunction, lipid peroxidation and cellular death or senescence. Flavonols are polyphenolic compounds, widely distributed in the plant kingdom and found in high concentrations in vegetables, fruits and teas. Their neuroprotective effects are mainly related to their antioxidant, anti-proliferative and anti-inflammatory properties.
It was this paper's intention to contribute with an evidence analysis of recent studies approaching neuroprotective effects of flavonols and the potential to conduct human clinical studies.
本文基于对 PubMed 和 SciELO 数据库的文献检索，使用了“Flavonoids，Neuroprotection，Quercetin，Rutin，Isoquercitrin，Alzheimer，Parkinson，Huntington”等关键词及其组合。
我们收集了相关出版物，时间跨度为 2000 年至 2016 年，重点关注了具有神经学评估的黄酮醇潜力的体内和体外研究，并根据证据水平对研究进行了分类，以便阐明基于证据的文献及其在临床研究中的应用。此外，我们强调了黄酮醇在现代研究领域的重要性，指出其神经保护潜力及其作为多种神经退行性疾病的预防和治疗治疗的用途。神经退行性疾病，如阿尔茨海默病、帕金森病和亨廷顿病，是全球范围内的一个主要健康问题，具有巨大的财务影响。它们是多因素疾病，其发病机制相似，包括氧化应激、自由基形成、异常蛋白质动力学（降解和聚集）、线粒体功能障碍、脂质过氧化和细胞死亡或衰老。黄酮醇是广泛分布于植物界的多酚化合物，在蔬菜、水果和茶中含量较高。它们的神经保护作用主要与其抗氧化、抗增殖和抗炎特性有关。
本文旨在对近年来研究黄酮醇的神经保护作用及其进行人体临床研究的潜力进行证据分析。
