药物超敏反应导致肉芽肿性间质性肾炎。
Drug hypersensitivity causing granulomatous interstitial nephritis.
作者信息
Singer D R, Simpson J G, Catto G R, Johnston A W
机构信息
Woodend General Hospital, Aberdeen, Scotland.
出版信息
Am J Kidney Dis. 1988 Apr;11(4):357-9. doi: 10.1016/s0272-6386(88)80144-6.
In association with treatment for pharyngitis, a 47-year-old white man developed a systemic illness with fever, myalgia, episcleritis, hemoptysis, pleurisy, eosinophilia, and renal impairment. Renal biopsy revealed granulomatous interstitial nephritis, which resolved due to no specific treatment other than withdrawing all medication. Both the severe systemic manifestations and spontaneous recovery are unusual in association with drug-induced granulomatous nephritis. The drugs that may have caused the reaction included dihydrocodeine, phenylpropanolamine, erythromycin, and amoxycillin. Although the latter three drugs have been previously implicated in the development of interstitial nephritis, there have been no previous reports of granulomatous interstitial nephritis with any of these drugs.
在治疗咽炎的过程中，一名47岁的白人男性出现了一种全身性疾病，伴有发热、肌痛、巩膜外层炎、咯血、胸膜炎、嗜酸性粒细胞增多和肾功能损害。肾活检显示为肉芽肿性间质性肾炎，除停用所有药物外未进行特殊治疗，病情得以缓解。严重的全身表现和自发恢复在药物性肉芽肿性肾炎中并不常见。可能引起该反应的药物包括二氢可待因、苯丙醇胺、红霉素和阿莫西林。尽管后三种药物此前曾被认为与间质性肾炎的发生有关，但此前尚无关于这些药物导致肉芽肿性间质性肾炎的报道。
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