Tang Yufei, Chen Lei, Duan Zihao, Zhao Kang, Wu Zixiang
Department of Materials Science and Engineering, Xi'an University of Technology, Xi'an 710048, PR China.
Department of Materials Science and Engineering, Xi'an University of Technology, Xi'an 710048, PR China.
Mater Sci Eng C Mater Biol Appl. 2021 Jan;120:111699. doi: 10.1016/j.msec.2020.111699. Epub 2020 Nov 4.
Barium titanate (BaTiO) has been used as a bone implant material because of its piezoelectric properties and the ability to promote cell growth when combined with hydroxyapatite. However, the brittleness of BaTiO inhibits its use as a bone replacement material at load-bearing sites, and the reduction of BaTiO content in the composite reduces its piezoelectric effect on bone growth. In this study, we explored a preparation method, which included directional freeze casting and self-solidification of bone cement, to obtain 1-3-type BaTiO/PMMA bio-piezoelectric composites with a lamellar structure. The lamellar BaTiO layer through the composite from the bottom to the top significantly improved the piezoelectric properties of the composite. In addition, the dendritic ceramic bridges on the BaTiO pore walls can improve the compressive strength and elastic modulus of BaTiO/PMMA bio-piezoelectric composites with a lamellar structure. More importantly, it was found that polarized lamellar BaTiO could induce osteoblasts to grow in the direction of the BaTiO layers. When the width of the BaTiO layer was in the range of 8-21 μm, osteoblasts along the BaTiO layer showed well growth, which can be of great value for the production of biomimetic bone units.
钛酸钡（BaTiO）因其压电特性以及与羟基磷灰石结合时促进细胞生长的能力，已被用作骨植入材料。然而，BaTiO的脆性限制了其在承重部位作为骨替代材料的应用，并且复合材料中BaTiO含量的降低会削弱其对骨生长的压电效应。在本研究中，我们探索了一种制备方法，包括定向冷冻铸造和骨水泥自固化，以获得具有层状结构的1-3型BaTiO/PMMA生物压电复合材料。贯穿复合材料从底部到顶部的层状BaTiO层显著改善了复合材料的压电性能。此外，BaTiO孔壁上的树枝状陶瓷桥可以提高具有层状结构的BaTiO/PMMA生物压电复合材料的抗压强度和弹性模量。更重要的是，发现极化的层状BaTiO可以诱导成骨细胞沿BaTiO层的方向生长。当BaTiO层的宽度在8-21μm范围内时，沿BaTiO层的成骨细胞生长良好，这对于仿生骨单元的生产具有重要价值。
