Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy; First College of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy.
Mater Sci Eng C Mater Biol Appl. 2021 Jan;120:111760. doi: 10.1016/j.msec.2020.111760. Epub 2020 Dec 3.
The role of Traditional Chinese Medicine (TCM), especially herbs or herbal extracts, in treating diseases has received increasing attention. This review focuses on the use of herbal extracts as signaling molecules and functional materials in the field of orthopedics, biomaterial science and bone tissue engineering strategies. A literature review using both Chinese and English references on herbs and herbal extracts based on TCM theory used in orthopedics and biomaterial science was performed. We discuss the efficacy of herbs, the active extracts from these herbs, the combination of herbal extracts and biomaterials and, finally, the application of herbal extracts to the biomaterials specific to orthopedics. Only a few studies have confirmed the feasibility of applying herbal extracts to biomaterials to improve the role of biomaterials and/or optimize drug delivery and release in orthopedics. In this context, this review reveals a new and promising direction for herbal extracts, where the use of herbal extracts based on TCM systemic treatment, can change the limited modern medicine view of biomaterials as "only for local treatment" when considering its efficacy.
中药（TCM），尤其是草药或草药提取物，在治疗疾病方面受到越来越多的关注。本综述重点介绍了草药提取物作为信号分子和功能材料在骨科、生物材料科学和骨组织工程策略中的应用。使用中文和英文的参考文献，对基于 TCM 理论在骨科和生物材料科学中使用的草药和草药提取物进行了文献回顾。我们讨论了草药的功效、这些草药的活性提取物、草药提取物与生物材料的结合，以及草药提取物在骨科专用生物材料中的应用。只有少数研究证实了将草药提取物应用于生物材料以提高生物材料的作用和/或优化骨科药物输送和释放的可行性。在这种情况下，本综述为草药提取物揭示了一个新的、有前途的方向，基于 TCM 系统治疗的草药提取物的使用，可以改变现代医学将生物材料视为“仅用于局部治疗”的局限性观点，从而考虑其疗效。
