Shi Guiwen, Yang Chaohua, Wang Qing, Wang Song, Wang Gaoju, Ao Rongguang, Li Dejian
Department of Orthopaedics, Affiliated Hospital of Southwest Medical University, Luzhou, China.
Department of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Front Bioeng Biotechnol. 2022 Feb 18;10:851561. doi: 10.3389/fbioe.2022.851561. eCollection 2022.
Bone is a dynamic organ that has the ability to repair minor injuries via regeneration. However, large bone defects with limited regeneration are debilitating conditions in patients and cause a substantial clinical burden. Bone tissue engineering (BTE) is an alternative method that mainly involves three factors: scaffolds, biologically active factors, and cells with osteogenic potential. However, active factors such as bone morphogenetic protein-2 (BMP-2) are costly and show an unstable release. Previous studies have shown that compounds of traditional Chinese medicines (TCMs) can effectively promote regeneration of bone defects when administered locally and systemically. However, due to the low bioavailability of these compounds, many recent studies have combined TCM compounds with materials to enhance drug bioavailability and bone regeneration. Hence, the article comprehensively reviewed the local application of TCM compounds to the materials in the bone regeneration and . The compounds included icariin, naringin, quercetin, curcumin, berberine, resveratrol, ginsenosides, and salvianolic acids. These findings will contribute to the potential use of TCM compound-loaded materials in BTE.
骨骼是一种动态器官，具有通过再生修复轻微损伤的能力。然而，再生能力有限的大骨缺损会使患者身体衰弱，并造成巨大的临床负担。骨组织工程（BTE）是一种替代方法，主要涉及三个要素：支架、生物活性因子和成骨潜能细胞。然而，诸如骨形态发生蛋白-2（BMP-2）等活性因子成本高昂且释放不稳定。先前的研究表明，中药（TCM）化合物在局部和全身给药时可有效促进骨缺损的再生。然而，由于这些化合物的生物利用度较低，最近许多研究将中药化合物与材料结合以提高药物生物利用度和促进骨再生。因此，本文全面综述了中药化合物在骨再生中对材料的局部应用。这些化合物包括淫羊藿苷、柚皮苷、槲皮素、姜黄素、小檗碱、白藜芦醇、人参皂苷和丹酚酸。这些发现将有助于含中药化合物材料在骨组织工程中的潜在应用。
