Gai Cong, Qiang Tianyao, Zhang Yuxin, Chai Yuan, Feng Wandi, Sun Hongmei
Department of Anatomy, School of Preclinical Medicine, Beijing University of Chinese Medicine.
Department of Research and Education, Beijing Ditan Hospital, Capital Medical University.
Medicine (Baltimore). 2021 Jan 22;100(3):e23010. doi: 10.1097/MD.0000000000023010.
Parkinson disease (PD) is a worldwide spread neurodegenerative disorder. Dopamine replacement therapy is currently the mainstream treatment, which can alleviate the symptoms but induces motor complications. Electroacupuncture (EA) is beneficial for PD as an alternative medicine. However, few reliable clinical trials or objective systematic reviews are available to give a verdict on the effectiveness of EA in the treatment of PD. Thus, we evaluate the evidence for EA in PD patients by conducting this meta-analysis.
PubMed, Cochrane Library, EMBASE, China National Knowledge Infrastructure, Chinese Scientific and Technology Journal database, WanFang Digital Periodicals, and Chinese Biomedical Literature Database (SinoMed) will be systematically searched for evidence by 2 authors individually. The analysis will be conducted by RevMan 5.3 software according to Cochrane Handbook.
The efficacy and safety of EA for PD will be comprehensively assessed from the outcomes, including the effectiveness rate, scores of Unified Parkinson Disease Rating Scale, and Webster scale, superoxide dismutase, lipid peroxides, and dopamine content.
This systematic review will provide evidence for whether EA can treatment PD.
PROSPERO CRD42019120956.
帕金森病（PD）是一种在全球范围内传播的神经退行性疾病。多巴胺替代疗法是目前的主流治疗方法，它可以缓解症状，但会引发运动并发症。电针作为一种替代医学对帕金森病有益。然而，很少有可靠的临床试验或客观的系统评价来判定电针治疗帕金森病的有效性。因此，我们通过进行这项荟萃分析来评估电针治疗帕金森病患者的证据。
两名作者将分别系统检索PubMed、Cochrane图书馆、EMBASE、中国知网、中国科技期刊数据库、万方数据期刊和中国生物医学文献数据库（SinoMed）以获取证据。将根据Cochrane手册使用RevMan 5.3软件进行分析。
将从有效率、统一帕金森病评定量表评分、韦伯斯特量表评分、超氧化物歧化酶、脂质过氧化物和多巴胺含量等结果全面评估电针治疗帕金森病的疗效和安全性。
本系统评价将为电针是否能治疗帕金森病提供证据。
PROSPERO CRD42019120956。
