Kailath E J, Goldstein E, Wagner F H
Department of Internal Medicine, School of Medicine, University of California, Davis.
Am J Med Sci. 1988 Mar;295(3):216-7. doi: 10.1097/00000441-198803000-00010.
In summary, we describe a case of central nervous system infection with O. xanthineolytica in which the infecting microbe probably was engrafted on a ventricular shunt. The bacteria caused a smoldering meningitis that did not respond to penicillin and rifampin despite in vitro sensitivity, presumably because of inadequate cerebrospinal fluid penetration of the penicillin and the recognized difficulty of eradicating bacteria from contaminated shunts. Removal of the shunt and continued treatment with penicillin and rifampin resulted in cure.
总之，我们描述了一例由解黄嘌呤欧文氏菌引起的中枢神经系统感染病例，感染微生物可能附着在脑室分流管上。尽管体外药敏试验显示该细菌对青霉素和利福平敏感，但该细菌引发了一种隐匿性脑膜炎，对这两种药物均无反应，推测原因是青霉素在脑脊液中的渗透不足，以及从受污染的分流管中根除细菌存在公认的困难。移除分流管并继续使用青霉素和利福平治疗后得以治愈。
