Harris J Johnisha, Rajasekar Arvina
Department of Periodontology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India.
Odontology. 2025 Apr 15. doi: 10.1007/s10266-025-01106-4.
This randomized controlled clinical trial aimed to assess the effectiveness of antimicrobial photodynamic therapy as an adjunct to scaling and root planing in chronic periodontitis patients in terms of plaque index, gingival index, probing pocket depth, clinical attachment level, total antioxidant capacity, total oxidative status and oxidative stress index. 40 chronic periodontitis patients were enrolled. In each patient, the quadrants were divided into two sides (left and right); one side (2 quadrants) was randomly assigned to group 1: SRP (control) and the other side (2 quadrants) was assigned to group 2: SRP + a-PDT (test). The clinical and biochemical parameters were measured at baseline and 3 months. Independent t test and paired t test were used to compare between and within groups respectively. At 3rd month, group 2 showed significant improvement (p ≤ 0.05) in terms of clinical (PI, GI, PPD) and biochemical parameters (TAOC, TOS, OSI) than group 1. However, there was no significant difference in terms of CAL (p > 0.05). a-PDT, when used as an adjunct to SRP can positively influence periodontal parameters and oxidative stress biomarkers, thereby restoring the oxidative and antioxidant balance in periodontal tissues nurturing it from disease to health.
这项随机对照临床试验旨在评估在慢性牙周炎患者中，抗菌光动力疗法作为龈下刮治术和根面平整术辅助治疗手段，在菌斑指数、牙龈指数、探诊深度、临床附着水平、总抗氧化能力、总氧化状态和氧化应激指数方面的有效性。纳入了40例慢性牙周炎患者。对于每位患者，将象限分为两侧（左侧和右侧）；一侧（2个象限）随机分配至第1组：龈下刮治术和根面平整术（对照组），另一侧（2个象限）分配至第2组：龈下刮治术和根面平整术 + 抗菌光动力疗法（试验组）。在基线和3个月时测量临床和生化参数。分别使用独立t检验和配对t检验在组间和组内进行比较。在第3个月时，第2组在临床（菌斑指数、牙龈指数、探诊深度）和生化参数（总抗氧化能力、总氧化状态、氧化应激指数）方面比第1组有显著改善（p≤0.05）。然而，在临床附着水平方面没有显著差异（p>0.05）。抗菌光动力疗法作为龈下刮治术和根面平整术的辅助手段，可以对牙周参数和氧化应激生物标志物产生积极影响，从而恢复牙周组织中的氧化和抗氧化平衡，使其从疾病状态恢复到健康状态。
