Hughes Alison H, Magot Florent, Tawfike Ahmed F, Rad-Menéndez Cecilia, Thomas Naomi, Young Louise C, Stucchi Laura, Carettoni Daniele, Stanley Michele S, Edrada-Ebel RuAngelie, Duncan Katherine R
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK.
Department of Pharmacognosy, Faculty of Pharmacy, Helwan University, Cairo 11795, Egypt.
Microorganisms. 2021 Feb 3;9(2):311. doi: 10.3390/microorganisms9020311.
With more than 156,000 described species, eukaryotic algae (both macro- and micro-algae) are a rich source of biological diversity, however their chemical diversity remains largely unexplored. Specialised metabolites with promising biological activities have been widely reported for seaweeds, and more recently extracts from microalgae have exhibited activity in anticancer, antimicrobial, and antioxidant screens. However, we are still missing critical information on the distinction of chemical profiles between macro- and microalgae, as well as the chemical space these metabolites cover. This study has used an untargeted comparative metabolomics approach to explore the chemical diversity of seven seaweeds and 36 microalgal strains. A total of 1390 liquid chromatography-mass spectrometry (LC-MS) features were detected, representing small organic algal metabolites, with no overlap between the seaweeds and microalgae. An in-depth analysis of four strains shows that environmental factors may play a larger role than phylogeny when classifying their metabolomic profiles.
真核藻类（包括大型藻类和微型藻类）有超过15.6万个已描述的物种，是生物多样性的丰富来源，然而它们的化学多样性在很大程度上仍未得到探索。具有潜在生物活性的特殊代谢产物在海藻中已有广泛报道，最近微型藻类提取物在抗癌、抗菌和抗氧化筛选中也表现出活性。然而，我们仍然缺乏有关大型藻类和微型藻类化学特征差异以及这些代谢产物所涵盖的化学空间的关键信息。本研究采用非靶向比较代谢组学方法，探索了7种海藻和36种微型藻株的化学多样性。共检测到1390个液相色谱 - 质谱（LC-MS）特征峰，代表小型有机藻类代谢产物，海藻和微型藻类之间没有重叠。对4个藻株的深入分析表明，在分类其代谢组学特征时，环境因素可能比系统发育发挥更大的作用。
