Department of Respiratory Medicine, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan.
Department of Respiratory Medicine, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan.
Respir Investig. 2021 May;59(3):377-381. doi: 10.1016/j.resinv.2020.12.005. Epub 2021 Jan 21.
A 70-year-old Japanese man contracted severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and required oxygen to maintain oxygen saturation (>90%), 5 weeks after onset of coronavirus disease 2019 (COVID-19) symptoms. Transbronchial lung cryobiopsy revealed pathological features of organizing pneumonia with alveolar epithelial injury, and prednisolone administration led to alleviation of respiratory symptoms and recovery of respiratory function. This case report is the first to demonstrate the use of corticosteroids to successfully treat post-COVID-19 respiratory failure in a patient with biopsy-proven organizing pneumonia. We propose that steroid treatment be considered for patients with persistent respiratory dysfunction as COVID-19 pneumonia sequelae.
一位 70 岁的日本男性感染了严重急性呼吸综合征冠状病毒 2（SARS-CoV-2），需要吸氧才能维持氧饱和度（>90%），在出现 2019 年冠状病毒病（COVID-19）症状 5 周后。经支气管肺冷冻活检显示出机化性肺炎的病理特征，伴有肺泡上皮损伤，给予泼尼松龙治疗后，呼吸症状得到缓解，呼吸功能恢复。本病例报告首次证明了皮质类固醇成功治疗了经活检证实为机化性肺炎的 COVID-19 后呼吸衰竭患者。我们建议对持续存在呼吸功能障碍的 COVID-19 肺炎后遗症患者考虑进行类固醇治疗。
