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COVID-19 后迟发性机化性肺炎的发生:3 例经支气管冷冻活检诊断病例报告及文献复习。

Delayed-onset Organizing Pneumonia Emerging after Recovery from Coronavirus Disease 2019: A Report of Three Cases Diagnosed Using Transbronchial Cryobiopsy and a Review of the Literature.

机构信息

Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.

Department of Surgical Pathology, Hokkaido University Hospital, Japan.

出版信息

Intern Med. 2022 May 1;61(9):1403-1410. doi: 10.2169/internalmedicine.9016-21. Epub 2022 Mar 5.

Abstract

We present three cases with an atypical clinical course of organizing pneumonia (OP) secondary to coronavirus disease 2019 (COVID-19). Three patients were discharged with satisfactory improvement after standard steroid therapy for COVID-19. Shortly after the completion of treatment, the patients experienced a flare-up of symptoms. Imaging results showed new lesions in the lungs. Transbronchial lung cryobiopsy showed histological findings consistent with OP in all cases. Steroids were administered, and a good therapeutic response was observed. This report is the first to describe pathologically confirmed OP that developed after recovery from COVID-19. Careful follow-up is advisable for patients who have recovered from COVID-19.

摘要

我们报告了三例继发于 2019 冠状病毒病(COVID-19)的机化性肺炎(OP)的非典型临床经过。这 3 名患者在接受 COVID-19 标准类固醇治疗后出院时症状得到明显改善。在治疗完成后不久,患者出现症状加重。影像学结果显示肺部出现新病变。经支气管肺冷冻活检显示所有病例均存在符合 OP 的组织学发现。给予类固醇治疗后,观察到良好的治疗反应。本报告首次描述了 COVID-19 康复后发生的经病理证实的 OP。对于 COVID-19 已康复的患者,建议进行仔细随访。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfcd/9152860/22cc00eedc61/1349-7235-61-1403-g001.jpg

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