Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
Department of Surgical Pathology, Hokkaido University Hospital, Japan.
Intern Med. 2022 May 1;61(9):1403-1410. doi: 10.2169/internalmedicine.9016-21. Epub 2022 Mar 5.
We present three cases with an atypical clinical course of organizing pneumonia (OP) secondary to coronavirus disease 2019 (COVID-19). Three patients were discharged with satisfactory improvement after standard steroid therapy for COVID-19. Shortly after the completion of treatment, the patients experienced a flare-up of symptoms. Imaging results showed new lesions in the lungs. Transbronchial lung cryobiopsy showed histological findings consistent with OP in all cases. Steroids were administered, and a good therapeutic response was observed. This report is the first to describe pathologically confirmed OP that developed after recovery from COVID-19. Careful follow-up is advisable for patients who have recovered from COVID-19.
我们报告了三例继发于 2019 冠状病毒病(COVID-19)的机化性肺炎(OP)的非典型临床经过。这 3 名患者在接受 COVID-19 标准类固醇治疗后出院时症状得到明显改善。在治疗完成后不久,患者出现症状加重。影像学结果显示肺部出现新病变。经支气管肺冷冻活检显示所有病例均存在符合 OP 的组织学发现。给予类固醇治疗后,观察到良好的治疗反应。本报告首次描述了 COVID-19 康复后发生的经病理证实的 OP。对于 COVID-19 已康复的患者,建议进行仔细随访。