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同种异体单纯性角膜缘上皮移植:治疗双侧干细胞缺乏症的一种合适方法。

Allogeneic simple limbal epithelial transplantation: an appropriate treatment for bilateral stem cell deficiency.

机构信息

Cornea and Anterior Segment, LV Prasad Eye Institute, Bhubaneswar, Odisha, India.

Cornea and Anterior Segment, LV Prasad Eye Institute, Bhubaneswar, Odisha, India

出版信息

BMJ Case Rep. 2021 Feb 5;14(2):e239998. doi: 10.1136/bcr-2020-239998.

Abstract

A 39-year-old man presented with both eyes limbal stem cell deficiency status post chemical injury. He was managed initially with topical medications to subside the ocular surface inflammation. Over the course of subsequent visits, the fibrovascular pannus over the cornea gradually progressed, leading to further diminution of vision in left eye more than right eye. Since, the ocular surface was wet, the patient committed for lifelong immunosuppression and his brother consented to donate healthy limbal tissue; he underwent living-related allogeneic simple limbal epithelial transplantation in the left eye.

摘要

一位 39 岁男性,双眼化学伤后继发角膜缘干细胞缺乏。他最初接受了局部药物治疗以控制眼表炎症。在随后的就诊过程中,角膜上的纤维血管性血管翳逐渐进展,导致左眼视力下降较右眼更为明显。由于眼表湿润,患者需要终身接受免疫抑制治疗,他的兄弟也同意捐献健康的角膜缘组织;他在左眼接受了活体亲属同种异体单纯性角膜缘上皮移植。

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本文引用的文献

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Limbal Stem Cell Deficiency-Demography and Underlying Causes.角膜缘干细胞缺乏症——人口统计学和潜在病因。
Am J Ophthalmol. 2018 Apr;188:99-103. doi: 10.1016/j.ajo.2018.01.020. Epub 2018 Jan 31.
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Keratolimbal allograft.角膜缘移植片
Curr Opin Ophthalmol. 2017 Jul;28(4):377-381. doi: 10.1097/ICU.0000000000000374.
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Surgical Management of Bilateral Limbal Stem Cell Deficiency.双侧角膜缘干细胞缺乏的手术治疗。
Ocul Surf. 2016 Jul;14(3):350-64. doi: 10.1016/j.jtos.2016.02.006. Epub 2016 May 2.

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