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1
Allogeneic simple limbal epithelial transplantation: an appropriate treatment for bilateral stem cell deficiency.同种异体单纯性角膜缘上皮移植:治疗双侧干细胞缺乏症的一种合适方法。
BMJ Case Rep. 2021 Feb 5;14(2):e239998. doi: 10.1136/bcr-2020-239998.
2
Successful Outcome of Simultaneous Allogeneic Simple Limbal Epithelial Transplantation With Therapeutic Penetrating Keratoplasty (PKP) for Limbal Stem Cell Deficiency and Sterile Keratolysis After Chemical Injury.同种异体单纯性角膜缘上皮移植联合治疗性穿透性角膜移植治疗化学伤后角膜缘干细胞缺乏和无菌性角膜溶解的成功结果。
Cornea. 2021 Jun 1;40(6):780-782. doi: 10.1097/ICO.0000000000002576.
3
In-vivo expansion of autologous limbal stem cell using simple limbal epithelial transplantation for treatment of limbal stem cell deficiency.采用简单的角膜缘上皮移植术进行自体角膜缘干细胞的体内扩增以治疗角膜缘干细胞缺乏症。
BMJ Case Rep. 2013 May 22;2013:bcr2013009247. doi: 10.1136/bcr-2013-009247.
4
Reconstruction of damaged corneas by transplantation of autologous limbal epithelial cells.通过自体角膜缘上皮细胞移植重建受损角膜。
N Engl J Med. 2000 Jul 13;343(2):86-93. doi: 10.1056/NEJM200007133430202.
5
Epithelial transplantation for the management of severe ocular surface disease.上皮移植治疗严重眼表疾病
Trans Am Ophthalmol Soc. 1996;94:677-743.
6
Midterm results of cultivated autologous and allogeneic limbal epithelial transplantation in limbal stem cell deficiency.自体和异体培养角膜缘上皮移植治疗角膜缘干细胞缺乏症的中期结果
Dev Ophthalmol. 2010;45:57-70. doi: 10.1159/000315020. Epub 2010 May 18.
7
Limbal autografting: comparison of results in the acute and chronic phases of ocular surface burns.角膜缘自体移植术:眼表烧伤急性期和慢性期结果的比较。
Cornea. 1999 Mar;18(2):164-71. doi: 10.1097/00003226-199903000-00004.
8
Surgical rehabilitation following ocular chemical injury.眼部化学伤后的手术康复
Cutan Ocul Toxicol. 2014 Mar;33(1):42-8. doi: 10.3109/15569527.2013.796477. Epub 2013 May 28.
9
Limbal allografting from living-related donors to treat partial limbal deficiency secondary to ocular chemical burns.来自活体亲属供体的角膜缘移植术治疗眼部化学烧伤继发的部分角膜缘缺损。
Arch Ophthalmol. 2011 Oct;129(10):1267-73. doi: 10.1001/archophthalmol.2011.251.
10
Successful management of immunological rejection following allogeneic simple limbal epithelial transplantation (SLET) for bilateral ocular burns.异体单纯角膜缘上皮移植术(SLET)治疗双眼眼烧伤后免疫排斥反应的成功管理。
BMJ Case Rep. 2013 Mar 14;2013:bcr2013009051. doi: 10.1136/bcr-2013-009051.

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1
Limbal stem cell deficiency approaches and limbal niche restoration.角膜缘干细胞缺乏症的治疗方法及角膜缘微环境的恢复
Indian J Ophthalmol. 2025 Apr 1;73(4):468-482. doi: 10.4103/IJO.IJO_464_25. Epub 2025 Mar 27.
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Femtosecond laser-assisted large-diameter lamellar corneal-limbal keratoplasty in ocular chemical burns.飞秒激光辅助下大直径板层角膜缘移植术治疗眼部化学伤
Am J Ophthalmol Case Rep. 2024 Dec 27;37:102246. doi: 10.1016/j.ajoc.2024.102246. eCollection 2025 Mar.
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Surgical application of Ong speculum in simple limbal epithelial transplantation and pterygium surgery.Ong 窥器在单纯性角膜缘上皮移植和翼状胬肉手术中的应用
Indian J Ophthalmol. 2023 Mar;71(3):994-995. doi: 10.4103/IJO.IJO_2528_22.
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Allogeneic simple limbal epithelial transplantation for bilateral limbal stem cell deficiency in chronic vernal keratoconjunctivitis: A case report.同种异体单纯角膜缘上皮移植治疗慢性春季角结膜炎双侧角膜缘干细胞缺乏:一例报告
Int J Surg Case Rep. 2022 May;94:106968. doi: 10.1016/j.ijscr.2022.106968. Epub 2022 Mar 28.

本文引用的文献

1
Simple limbal epithelial transplantation (SLET): Review of indications, surgical technique, mechanism, outcomes, limitations, and impact.简单性角膜缘上皮移植术(SLET):适应证、手术技术、机制、结果、局限性及影响的综述。
Indian J Ophthalmol. 2019 Aug;67(8):1265-1277. doi: 10.4103/ijo.IJO_117_19.
2
Twenty years of limbal epithelial therapy: an update on managing limbal stem cell deficiency.二十年的角膜缘上皮治疗:角膜缘干细胞缺乏症管理的最新进展
BMJ Open Ophthalmol. 2018 Aug 10;3(1):e000164. doi: 10.1136/bmjophth-2018-000164. eCollection 2018.
3
Limbal Stem Cell Deficiency-Demography and Underlying Causes.角膜缘干细胞缺乏症——人口统计学和潜在病因。
Am J Ophthalmol. 2018 Apr;188:99-103. doi: 10.1016/j.ajo.2018.01.020. Epub 2018 Jan 31.
4
Keratolimbal allograft.角膜缘移植片
Curr Opin Ophthalmol. 2017 Jul;28(4):377-381. doi: 10.1097/ICU.0000000000000374.
5
Surgical Management of Bilateral Limbal Stem Cell Deficiency.双侧角膜缘干细胞缺乏的手术治疗。
Ocul Surf. 2016 Jul;14(3):350-64. doi: 10.1016/j.jtos.2016.02.006. Epub 2016 May 2.
6
Live Related versus Cadaveric Limbal Allograft in Limbal Stem Cell Deficiency.活体亲属供体与尸体角膜缘移植在角膜缘干细胞缺乏症中的应用比较
Ocul Immunol Inflamm. 2015 Jun;23(3):232-9. doi: 10.3109/09273948.2014.902076. Epub 2014 Jul 24.
7
Successful management of immunological rejection following allogeneic simple limbal epithelial transplantation (SLET) for bilateral ocular burns.异体单纯角膜缘上皮移植术(SLET)治疗双眼眼烧伤后免疫排斥反应的成功管理。
BMJ Case Rep. 2013 Mar 14;2013:bcr2013009051. doi: 10.1136/bcr-2013-009051.
8
Clinical outcomes of xeno-free allogeneic cultivated limbal epithelial transplantation for bilateral limbal stem cell deficiency.无饲养物异体培养角膜缘上皮移植治疗双侧角膜缘干细胞缺陷的临床疗效。
Br J Ophthalmol. 2012 Dec;96(12):1504-9. doi: 10.1136/bjophthalmol-2012-301869. Epub 2012 Sep 13.
9
Allogenic limbo-keratoplasty with conjunctivoplasty, mitomycin C, and amniotic membrane for bilateral limbal stem cell deficiency.同种异体角膜缘-结膜成形术联合丝裂霉素 C 和羊膜移植治疗双侧角膜缘干细胞缺陷。
Ophthalmology. 2012 May;119(5):930-7. doi: 10.1016/j.ophtha.2011.10.039. Epub 2012 Feb 11.
10
Side effects of systemic cyclosporine in patients not undergoing transplantation.未接受移植患者使用全身性环孢素的副作用。
Am J Med. 1984 Oct;77(4):652-6. doi: 10.1016/0002-9343(84)90356-5.

同种异体单纯性角膜缘上皮移植:治疗双侧干细胞缺乏症的一种合适方法。

Allogeneic simple limbal epithelial transplantation: an appropriate treatment for bilateral stem cell deficiency.

机构信息

Cornea and Anterior Segment, LV Prasad Eye Institute, Bhubaneswar, Odisha, India.

Cornea and Anterior Segment, LV Prasad Eye Institute, Bhubaneswar, Odisha, India

出版信息

BMJ Case Rep. 2021 Feb 5;14(2):e239998. doi: 10.1136/bcr-2020-239998.

DOI:10.1136/bcr-2020-239998
PMID:33547103
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7871270/
Abstract

A 39-year-old man presented with both eyes limbal stem cell deficiency status post chemical injury. He was managed initially with topical medications to subside the ocular surface inflammation. Over the course of subsequent visits, the fibrovascular pannus over the cornea gradually progressed, leading to further diminution of vision in left eye more than right eye. Since, the ocular surface was wet, the patient committed for lifelong immunosuppression and his brother consented to donate healthy limbal tissue; he underwent living-related allogeneic simple limbal epithelial transplantation in the left eye.

摘要

一位 39 岁男性,双眼化学伤后继发角膜缘干细胞缺乏。他最初接受了局部药物治疗以控制眼表炎症。在随后的就诊过程中,角膜上的纤维血管性血管翳逐渐进展,导致左眼视力下降较右眼更为明显。由于眼表湿润,患者需要终身接受免疫抑制治疗,他的兄弟也同意捐献健康的角膜缘组织;他在左眼接受了活体亲属同种异体单纯性角膜缘上皮移植。