Haapala Eero A, Väistö Juuso, Ihalainen Johanna K, González Claudia Tomaselli, Leppänen Marja H, Veijalainen Aapo, Sallinen Taisa, Eloranta Aino-Maija, Ekelund Ulf, Schwab Ursula, Brage Soren, Atalay Mustafa, Lakka Timo A
Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.
Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.
Eur J Sport Sci. 2022 Jun;22(6):906-915. doi: 10.1080/17461391.2021.1892830. Epub 2021 Mar 14.
We investigated the associations of physical activity (PA), sedentary time (ST), and diet quality with biomarkers of inflammation in 390 children (192 girls, 198 boys) aged 6-8 years. PA energy expenditure (PAEE), light PA, moderate PA (MPA), vigorous PA (VPA), moderate-to-vigorous PA (MVPA), and ST were assessed by combined movement and heart rate sensor. Finnish Children Healthy Eating Index was calculated using data from 4 d food records. Body fat percentage (BF%) was measured by dual-energy X-ray absorptiometry. High-sensitivity C-reactive protein (Hs-CRP), leptin, interleukin-6 (IL-6), adiponectin, tumour necrosis factor-α, and glycoprotein acetyls were measured from fasting blood samples. PAEE, MPA, VPA, and MVPA were inversely associated with hs-CRP (β=-191 to -139, 95% CI=-0.294 to -0.024), leptin (β=-0.409 to -0.301, 95% CI=-0.499 to -0.107), IL-6 (β=-0.136 to -0.104, 95% CI=-0.240 to -0.001) and PAEE, MPA, and MVPA were inversely associated with glycoprotein acetyls (β=-0.117 to -0.103, 95% CI=-0.213 to -0.001). ST was directly associated with hs-CRP (β=0.170, 95% CI=0.070-0.269), leptin (β=0.355, 95% CI=0.265-0.445), and IL-6 (β=0.105, 95% CI=0.005-0.205). VPA was inversely associated with hs-CRP, leptin, and IL-6 in children with higher BF% (β=-0.344 to -0.181, 95% CI=-0.477 to -0.033) but not among children with lower BF% (β=-0.007-0.033, 95% CI=-0.183-0.184). In conclusion, PA was inversely and ST directly associated with circulating levels of biomarkers of inflammation among children. Furthermore, we observed that PA was inversely associated with these biomarkers for inflammation in children with a higher BF%. HighlightsSystemic inflammation, as indicated by increased circulating concentrations of biomarkers for inflammation, may be important in causal pathways leading to insulin resistance, sub-clinical atherosclerosis, and eventually clinical manifestations of cardiovascular diseases.Higher levels of physical activity and lower levels of sedentary time were associated with more favourable inflammatory profile.Body fat percentage modified these associations and especially vigorous intensity physical activity was inversely associated with biomarkers of inflammation on children with higher body fat percentage but not in children with lower body fat percentage.
我们调查了390名6至8岁儿童（192名女孩，198名男孩）的身体活动（PA）、久坐时间（ST）和饮食质量与炎症生物标志物之间的关联。通过运动和心率传感器组合评估PA能量消耗（PAEE）、轻度PA、中度PA（MPA）、剧烈PA（VPA）、中度至剧烈PA（MVPA）和ST。使用4天食物记录数据计算芬兰儿童健康饮食指数。通过双能X线吸收法测量体脂百分比（BF%）。从空腹血样中测量高敏C反应蛋白（Hs-CRP）、瘦素、白细胞介素-6（IL-6）、脂联素、肿瘤坏死因子-α和糖蛋白乙酰化物。PAEE、MPA、VPA和MVPA与Hs-CRP（β=-191至-139，95%CI=-0.294至-0.024）、瘦素（β=-0.409至-0.301，95%CI=-0.499至-0.107）、IL-6（β=-0.136至-0.104，95%CI=-0.240至-0.001）呈负相关，PAEE、MPA和MVPA与糖蛋白乙酰化物呈负相关（β=-0.117至-0.103，95%CI=-0.213至-0.001）。ST与Hs-CRP（β=0.170，95%CI=0.070 - 0.269）、瘦素（β=0.355，95%CI=0.265 - 0.445）和IL-6（β=0.105，95%CI=0.005 - 0.205）呈正相关。在BF%较高的儿童中，VPA与Hs-CRP、瘦素和IL-6呈负相关（β=-0.344至-0.181，95%CI=-0.477至-0.033），但在BF%较低的儿童中无此关联（β=-0.007 - 0.033，95%CI=-0.183至-0.184）。总之，PA与儿童炎症生物标志物的循环水平呈负相关，ST与之呈正相关。此外，我们观察到PA与BF%较高儿童的这些炎症生物标志物呈负相关。要点：循环中炎症生物标志物浓度升高所表明的全身炎症，可能在导致胰岛素抵抗、亚临床动脉粥样硬化以及最终心血管疾病临床表现的因果途径中起重要作用。较高水平的身体活动和较低水平的久坐时间与更有利的炎症特征相关。体脂百分比改变了这些关联，特别是剧烈强度的身体活动与BF%较高儿童的炎症生物标志物呈负相关，但在BF%较低的儿童中并非如此。
