系统性硬化症血管并发症的治疗：肾危象和指（趾）溃疡的诊断和治疗的最佳方法是什么？
Treatment of Vascular Complications in Systemic Sclerosis: What Is the Best Approach to Diagnosis and Management of Renal Crisis and Digital Ulcers?
机构信息
Department of Rheumatology, Tameside and Glossop Integrated Care NHS Foundation Trust, Ashton-under-Lyne, UK; Division of Musculoskeletal and Dermatological Sciences, The University of Manchester, Manchester, UK.
Division of Musculoskeletal and Dermatological Sciences, The University of Manchester, Manchester, UK; Northern Care Alliance NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
出版信息
Rheum Dis Clin North Am. 2023 May;49(2):263-277. doi: 10.1016/j.rdc.2023.01.004.
Vasculopathy as exemplified by scleroderma renal crisis (SRC) and digital ulcers (DUs) is a cardinal feature of systemic sclerosis (SSc) and is associated with significant morbidity, including in patients with early disease. Prompt recognition and management is required to alleviate potentially irreversible damage from SSc-associated vasculopathy. Both SRC and DUs share many etiopathogenic drivers which inform the therapeutic strategy. The aim of our review was to describe the diagnosis and management of SRC and DUs in SSc, and to discuss unmet needs for future research.
血管病变以硬皮病肾危象（SRC）和指（趾）溃疡（DUs）为代表，是系统性硬化症（SSc）的一个主要特征，与显著的发病率相关，包括在疾病早期的患者中。需要及时识别和管理，以减轻与 SSc 相关的血管病变潜在的不可逆转损害。SRC 和 DUs 具有许多共同的发病机制驱动因素，为治疗策略提供了信息。我们的综述旨在描述 SSc 中 SRC 和 DUs 的诊断和管理，并讨论未来研究的未满足需求。
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