Division of Clinical Geriatrics, Department of Neurobiology, Center for Alzheimer Research, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Region Västra Götaland, Sahlgrenska University Hospital, Psychiatry Cognition and Old Age Psychiatry Clinic, Mölndal, Sweden; Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Mölndal, Sweden.
Neurobiol Aging. 2021 May;101:1-12. doi: 10.1016/j.neurobiolaging.2020.10.033. Epub 2021 Jan 12.
The association between cerebrospinal fluid (CSF) amyloid beta (Aβ) Aβ38 or Aβ40 and brain grey- and white matter integrity is poorly understood. We studied this in 213 cognitively normal 70-year-olds, and in subgroups defined by presence/absence of the APOE ε4 allele and Aβ pathology: Aβ-/APOE-, Aβ+/APOE-, Aβ-/APOE+ and Aβ+/APOE+. CSF Aβ was quantified using ELISA and genotyping for APOE was performed. Low CSF Aβ42 defined Aβ plaque pathology. Brain volumes were assessed using Freesurfer-5.3, and white matter integrity using tract-based statistics in FSL. Aβ38 and Aβ40 were positively correlated with cortical thickness, some subcortical volumes and white matter integrity in the total sample, and in 3 of the subgroups: Aβ-/APOE-, Aβ+/APOE- and Aβ-/APOE+. In Aβ+/APOE+ subjects, higher Aβ38 and Aβ40 were linked to reduced cortical thickness and subcortical volumes. We hypothesize that production of all Aβ species decrease in brain regions with atrophy. In Aβ+/APOE+, Aβ-dysregulation may be linked to cortical atrophy in which high Aβ levels is causing pathological changes in the gray matter of the brain.
脑脊液（CSF）淀粉样蛋白β（Aβ）Aβ38 或 Aβ40 与脑灰质和白质完整性之间的关联尚未得到充分理解。我们在 213 名认知正常的 70 岁老年人中研究了这一点，并根据 APOE ε4 等位基因和 Aβ 病理学的存在/不存在对亚组进行了定义：Aβ-/APOE-、Aβ+/APOE-、Aβ-/APOE+和 Aβ+/APOE+。使用 ELISA 定量 CSF Aβ，并进行 APOE 基因分型。低 CSF Aβ42 定义了 Aβ 斑块病理学。使用 Freesurfer-5.3 评估脑容量，使用 FSL 中的基于束流的统计数据评估白质完整性。在总样本以及 Aβ-/APOE-、Aβ+/APOE-和 Aβ-/APOE+这 3 个亚组中，Aβ38 和 Aβ40 与皮质厚度、一些皮质下体积和白质完整性呈正相关。在 Aβ+/APOE+受试者中，较高的 Aβ38 和 Aβ40 与皮质厚度和皮质下体积减少相关。我们假设所有 Aβ 物种的产生都会减少脑萎缩区域。在 Aβ+/APOE+中，Aβ 失调可能与皮质萎缩有关，其中高水平的 Aβ 会导致大脑灰质发生病理变化。
