通过反馈和前馈环记忆环境信号。
Memorizing environmental signals through feedback and feedforward loops.
机构信息
Section of Molecular Biology, Division of Biological Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
Section of Molecular Biology, Division of Biological Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
出版信息
Curr Opin Cell Biol. 2021 Apr;69:96-102. doi: 10.1016/j.ceb.2020.11.008. Epub 2021 Feb 4.
Abstract
Cells in diverse organisms can store the information of previous environmental conditions for long periods of time. This form of cellular memory adjusts the cell's responses to future challenges, providing fitness advantages in fluctuating environments. Many biological functions, including cellular memory, are mediated by specific recurring patterns of interactions among proteins and genes, known as 'network motifs.' In this review, we focus on three well-characterized network motifs - negative feedback loops, positive feedback loops, and feedforward loops, which underlie different types of cellular memories. We describe the latest studies identifying these motifs in various molecular processes and discuss how the topologies and dynamics of these motifs can enable memory encoding and storage.
摘要
不同生物的细胞可以长时间存储先前环境条件的信息。这种细胞记忆形式可以调整细胞对未来挑战的反应，在环境波动的情况下提供适应优势。许多生物学功能，包括细胞记忆，都是由蛋白质和基因之间特定的、反复出现的相互作用模式来介导的，这些模式被称为“网络基元”。在这篇综述中，我们专注于三种特征明显的网络基元——负反馈回路、正反馈回路和前馈回路，它们是不同类型细胞记忆的基础。我们描述了最新的研究，这些研究确定了这些基元在各种分子过程中的存在，并讨论了这些基元的拓扑结构和动力学如何使记忆编码和存储成为可能。
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