IDO2 在癌症中的新兴作用及其作为治疗靶点的潜力。
The emerging roles of IDO2 in cancer and its potential as a therapeutic target.
机构信息
Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
出版信息
Biomed Pharmacother. 2021 May;137:111295. doi: 10.1016/j.biopha.2021.111295. Epub 2021 Feb 4.
During the past decades, tryptophan metabolism disorder was discovered to play a vital and complex role in the development of cancer. Indoleamine 2,3-dioxygenase 2 (IDO2) is one of the initial and rate-limiting enzymes of the kynurenine pathway of tryptophan catabolism. Increasing evidence indicates that IDO2 is upregulated in some tumors and plays a role in the development of cancer. In spite of the growing body of research, few reviews focused on the role of IDO2 in cancer. Here, we review the emerging knowledge on the roles of IDO2 in cancer and its potential as a therapeutic target. Firstly, the main biological features and regulatory mechanisms are reviewed, after which we focus on the expression and roles of IDO2 in cancer. Finally, we discuss the potential of IDO2 as a therapeutic target for cancer treatment.
在过去几十年中，人们发现色氨酸代谢紊乱在癌症的发展中起着至关重要且复杂的作用。吲哚胺 2,3-双加氧酶 2（IDO2）是色氨酸分解代谢中犬尿氨酸途径的初始和限速酶之一。越来越多的证据表明，IDO2 在一些肿瘤中上调，并在癌症的发展中发挥作用。尽管研究越来越多，但很少有综述关注 IDO2 在癌症中的作用。在这里，我们综述了 IDO2 在癌症中的作用及其作为治疗靶点的潜力方面的新进展。首先，我们回顾了 IDO2 的主要生物学特征和调控机制，然后重点讨论了 IDO2 在癌症中的表达和作用。最后，我们讨论了 IDO2 作为癌症治疗的治疗靶点的潜力。
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