Targeting the Kynurenine Pathway: A Novel Approach in Tumor Therapy.

BACKGROUND

Cancer cells interact with their surroundings to promote tumour formation and metastasis, often requiring a constant supply of amino acids. The reprogramming of tryptophan (Trp) metabolism is highly activated in tumours, providing essential biological raw materials and energy for malignant tumour progression. Among these metabolic pathways, the kynurenine pathway (KP) plays a crucial role, making it a promising target for tumour therapy.

METHODS

This study comprehensively examines the roles of KP metabolites in tumour growth and evaluates therapeutic strategies targeting this pathway.

RESULTS

Targeting the KP in Trp metabolism presents new possibilities for tumour treatment. The study highlights various strategies, including traditional inhibition of key enzymes, novel drug delivery systems for enzyme targeting and mechanism-derived combination therapies. These approaches aim to enhance the precision and effectiveness of tumour therapy by modulating KP activity.

CONCLUSIONS

A deeper understanding of KP metabolism in tumour progression opens new avenues for therapeutic intervention.