Lin Shuoqi, Zheng Genggeng, Yan Yuxiang, Liao Tesen, Su Bohua, Zheng Dali
Expert Rev Mol Med. 2025 Mar 5;27:1-33. doi: 10.1017/erm.2025.5.
Cancer cells interact with their surroundings to promote tumour formation and metastasis, often requiring a constant supply of amino acids. The reprogramming of tryptophan (Trp) metabolism is highly activated in tumours, providing essential biological raw materials and energy for malignant tumour progression. Among these metabolic pathways, the kynurenine pathway (KP) plays a crucial role, making it a promising target for tumour therapy.
This study comprehensively examines the roles of KP metabolites in tumour growth and evaluates therapeutic strategies targeting this pathway.
Targeting the KP in Trp metabolism presents new possibilities for tumour treatment. The study highlights various strategies, including traditional inhibition of key enzymes, novel drug delivery systems for enzyme targeting and mechanism-derived combination therapies. These approaches aim to enhance the precision and effectiveness of tumour therapy by modulating KP activity.
A deeper understanding of KP metabolism in tumour progression opens new avenues for therapeutic intervention.
癌细胞与周围环境相互作用以促进肿瘤形成和转移，这通常需要持续供应氨基酸。色氨酸（Trp）代谢重编程在肿瘤中高度激活，为恶性肿瘤进展提供必需的生物原料和能量。在这些代谢途径中，犬尿氨酸途径（KP）起着关键作用，使其成为肿瘤治疗的一个有前景的靶点。
本研究全面考察了KP代谢产物在肿瘤生长中的作用，并评估了针对该途径的治疗策略。
靶向Trp代谢中的KP为肿瘤治疗带来了新的可能性。该研究突出了各种策略，包括传统的关键酶抑制、用于酶靶向的新型药物递送系统以及基于机制的联合疗法。这些方法旨在通过调节KP活性来提高肿瘤治疗的精准性和有效性。
对肿瘤进展过程中KP代谢的更深入理解为治疗干预开辟了新途径。
