Li Shaochen, Lv Min, Zhang Shaoyong, Xu Hui
College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi Province, China.
Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, College of Life Science, Huzhou University, Huzhou 313000, Zhejiang Province, China.
Mini Rev Med Chem. 2021;21(17):2551-2566. doi: 10.2174/1389557521666210125145321.
Derivatives of monosaccharides and oligosaccharides play important roles in biological processes. Monosaccharides are the single carbohydrate building blocks, such as glucose, xylose, and fructose. Oligosaccharides are composed of 2-10 monosaccharides, including disaccharides and trisaccharides. Moreover, monosaccharides, oligosaccharides and their derivatives are vital molecules with various biological properties, including anticancer activity, antiviral activity, insecticidal activity, antimicrobial activity, and antioxidant activity. This review covers a survey of structural modifications, biological activities, and mechanisms of action of monosaccharides, oligosaccharides and their derivatives. Additionally, their structure-activity relationships are also concluded.
单糖和寡糖的衍生物在生物过程中发挥着重要作用。单糖是单个的碳水化合物构建单元，如葡萄糖、木糖和果糖。寡糖由2至10个单糖组成，包括二糖和三糖。此外，单糖、寡糖及其衍生物是具有多种生物学特性的重要分子，包括抗癌活性、抗病毒活性、杀虫活性、抗菌活性和抗氧化活性。本综述涵盖了对单糖、寡糖及其衍生物的结构修饰、生物活性和作用机制的综述。此外，还总结了它们的构效关系。
