Tapia Héctor, Torres Pedro, Mateluna Carlos, Cáceres Mónica, Torres Vicente A
Institute for Research in Dental Sciences, Faculty of Dentistry, Universidad de Chile, Santiago, Chile.
Advanced Center for Chronic Diseases (ACCDiS), Universidad de Chile, Santiago, Chile.
iScience. 2024 Nov 1;27(12):111309. doi: 10.1016/j.isci.2024.111309. eCollection 2024 Dec 20.
Recent studies show that a group of salivary peptides, collectively known as histatins, are potent inducers of wound healing in both soft and hard tissues. Among these molecules, histatin-1 stands out for its ability to stimulate the repair of skin, oral mucosal, and osseous tissue. Remarkably, all these effects are associated with the capacity of histatin-1 to promote angiogenesis via inducing endothelial cell adhesion, migration, and signaling. These findings have opened new opportunities in the field of regenerative medicine, leading to an increasing number of articles and patents proposing therapeutic uses of histatin-1. However, this scenario raises a relevant concern regarding the appropriate use of these molecules, since, unlike the mode of action, little is known about the molecular mechanism by which they promote angiogenesis and wound healing. Recent studies shed light on the pharmacodynamics of histatin-1, by identifying the endothelial receptor that it binds and downstream signaling. This perspective will discuss current evidence on the role of histatins in wound healing and angiogenesis, emphasizing their impact on regenerative medicine.
最近的研究表明，一组统称为富组蛋白的唾液肽是软组织和硬组织伤口愈合的有效诱导剂。在这些分子中，富组蛋白-1因其刺激皮肤、口腔黏膜和骨组织修复的能力而脱颖而出。值得注意的是，所有这些作用都与富组蛋白-1通过诱导内皮细胞黏附、迁移和信号传导来促进血管生成的能力有关。这些发现为再生医学领域带来了新的机遇，导致越来越多的文章和专利提出富组蛋白-1的治疗用途。然而，这种情况引发了一个关于这些分子适当使用的相关问题，因为与作用方式不同，对于它们促进血管生成和伤口愈合的分子机制知之甚少。最近的研究通过鉴定富组蛋白-1结合的内皮受体和下游信号传导，阐明了其药效学。本综述将讨论关于富组蛋白在伤口愈合和血管生成中作用的当前证据，强调它们对再生医学的影响。
