Liu Zihao, Du Yaqi, Xu Shendan, Li Minting, Lu Xuemei, Tian Guangjie, Ye Jing, Zhao Bo, Wei Pengfei, Wang Yonglan
Zhongnuo Dental Hospital, Tianjin Nankai District, Tianjin 300101, China.
School and Hospital of Stomatology, Tianjin Medical University, Tianjin 30070, China.
iScience. 2023 Oct 14;26(11):108212. doi: 10.1016/j.isci.2023.108212. eCollection 2023 Nov 17.
Dental implants make it possible to replace teeth in more sophisticated ways. Nevertheless, peri-implantitis is one of the leading causes of implant failure, which can be avoided with proper soft tissue sealing. The aim of this study was to achieve the promotion of the synthesis of peri-implant epithelial hemidesmosome through Histatin 1 and porcine small intestinal submucosa (SIS) hydrogel to form a good peri-implant seal. The results show that hydrogel can improve the biological barrier function around implants by combining antibacterial, promoting soft tissue healing and promoting epithelial bonding. This means that the morphology and anti-infection ability of soft tissue are enhanced, which ensures the long-term stability of the implant.SIS-Hst1 hydrogel has certain clinical application in the prevention and early treatment of peri-implantitis. In conclusion, Hst1-SIS hydrogel, as a local administration system, provides experimental evidence for the prevention of peri-implant disease.
牙种植体使以更复杂的方式替换牙齿成为可能。然而，种植体周围炎是种植失败的主要原因之一，通过适当的软组织封闭可以避免。本研究的目的是通过组蛋白1和猪小肠黏膜下层（SIS）水凝胶促进种植体周围上皮半桥粒的合成，以形成良好的种植体周围封闭。结果表明，水凝胶通过结合抗菌、促进软组织愈合和促进上皮黏附，可改善种植体周围的生物屏障功能。这意味着软组织的形态和抗感染能力得到增强，从而确保种植体的长期稳定性。SIS-Hst1水凝胶在种植体周围炎的预防和早期治疗中具有一定的临床应用价值。总之，Hst1-SIS水凝胶作为一种局部给药系统，为预防种植体周围疾病提供了实验依据。
