Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
West China School of Stomatology, Sichuan University, Chengdu 610041, China.
Dig Liver Dis. 2021 Jul;53(7):809-816. doi: 10.1016/j.dld.2021.01.018. Epub 2021 Feb 4.
Accumulating evidence indicates a plausible association between inflammatory bowel diseases and the risk of adverse health outcomes. However, the conclusions are inconsistent. We aimed to perform an umbrella review of meta-analyses to appraise and grade the evidence of the association between inflammatory bowel diseases and the risk of adverse health outcomes.
Meta-analyses of observational studies that examined the associations between inflammatory bowel disease and the risk of adverse health outcomes in PubMed, EMBASE, and Web of Science were screened.
This umbrella review identified 25 meta-analyses, which yielded 123 effect estimates for 60 unique putative health outcomes. Patients with inflammatory bowel diseases had a higher risk of adverse health outcomes, including multiple cancers, cardiovascular disease, adverse pregnancy outcomes, adverse oral outcomes, and other adverse events. Moreover, inflammatory bowel diseases caused greater harm to health based on the presented evidence. However, none of the evidence was classified as "high" quality, only 15% was classified as "moderate," and 65% of outcomes were rated as "very low."
Patients with inflammatory bowel diseases had a higher risk of adverse health outcomes and further studies should be conducted to draw firmer conclusions.
越来越多的证据表明，炎症性肠病与不良健康结局风险之间存在合理关联。然而，结论并不一致。我们旨在进行一项荟萃分析的伞式评价，以评估和分级炎症性肠病与不良健康结局风险之间关联的证据。
筛选了在 PubMed、EMBASE 和 Web of Science 中检查炎症性肠病与不良健康结局风险之间关联的观察性研究的荟萃分析。
本伞式评价确定了 25 项荟萃分析，产生了 60 个独特的潜在健康结果的 123 个效应估计。炎症性肠病患者发生不良健康结局的风险更高，包括多种癌症、心血管疾病、不良妊娠结局、不良口腔结局和其他不良事件。此外，根据现有证据，炎症性肠病对健康造成了更大的危害。然而，没有任何证据被归类为“高质量”，只有 15%被归类为“中等”，65%的结果被评为“非常低”。
炎症性肠病患者发生不良健康结局的风险更高，需要进一步研究以得出更确凿的结论。
