Jiang Jingjing, Chen Lu, Sun Rui, Yu Ting, Jiang Shuyu, Chen Hong
School of Medicine, Southeast University, Nanjing, China.
Department of Gastroenterology, Zhongda Hospital, Southeast University, Nanjing, China.
Ther Adv Chronic Dis. 2023 Feb 28;14:20406223231156826. doi: 10.1177/20406223231156826. eCollection 2023.
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the digestive tract. The aetiology and pathogenesis of IBD are complex, which may lead to metabolic disorders. As a kind of metabolite, polyunsaturated fatty acid (PUFA) is closely related to IBD.
The aim of this study was to explore the correlation between the serum PUFAs and the pathogenesis of IBD.
The study is a hospital-based case-control study.
The serum free PUFAs of all participants, including 104 patients with IBD and 101 normal controls, were detected by liquid chromatography-mass spectrometry (LC-MS).
Compared with the normal control, the levels of C18:2, α-C18:3 (ALA), ɤ-C18:3, C20:4 (AA), C20:5 (EPA), ω-3 C22:5, ω-6 C22:5 and C22:6 (DHA) PUFAs in patients with Crohn's disease (CD) were obviously decreased. However, in patients with ulcerative colitis (UC), the levels of AA, EPA, ω-3 C22:5, ω-6 C22:5 and DHA were downregulated. The concentrations of seven PUFAs were significantly downregulated in the active CD group. In addition, four PUFAs had comparatively higher levels in the remission UC group.
The present study revealed substantial differences in the levels of serum fatty acids between normal controls and patients with IBD. In detail, patients with CD were deficient in PUFAs, including the essential fatty acids. Moreover, as the disease activity aggravated, some PUFAs decreased dramatically.
炎症性肠病（IBD）是一种消化道慢性炎症性疾病。IBD的病因和发病机制复杂，可能导致代谢紊乱。多不饱和脂肪酸（PUFA）作为一种代谢产物，与IBD密切相关。
本研究旨在探讨血清PUFAs与IBD发病机制之间的相关性。
本研究是一项基于医院的病例对照研究。
采用液相色谱-质谱联用（LC-MS）法检测所有参与者（包括104例IBD患者和101例正常对照）的血清游离PUFAs。
与正常对照相比，克罗恩病（CD）患者中C18:2、α-C18:3（ALA）、ɤ-C18:3、C20:4（AA）、C20:5（EPA）、ω-3 C22:5、ω-6 C22:5和C22:6（DHA）等PUFAs水平明显降低。然而，溃疡性结肠炎（UC）患者中AA、EPA、ω-3 C22:5、ω-6 C22:5和DHA水平下调。活动期CD组七种PUFAs浓度显著下调。此外，缓解期UC组四种PUFAs水平相对较高。
本研究揭示了正常对照与IBD患者血清脂肪酸水平存在显著差异。具体而言，CD患者缺乏PUFAs，包括必需脂肪酸。而且，随着疾病活动加剧，一些PUFAs急剧下降。
