Wu Kaiwen, Li Aoshuang, Liu Lei, Shu Tao, Xia Demeng, Sun Xiaobin
Department of Gastroenterology, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, Chengdu, Sichuan, China.
Medical Research Center, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, Chengdu, Sichuan, China.
Front Cardiovasc Med. 2022 Sep 2;9:927120. doi: 10.3389/fcvm.2022.927120. eCollection 2022.
Although epidemiological studies have shown a positive relationship between inflammatory bowel disease (IBD) and risk of cardiovascular disease (CVD) outcomes, a solid causal relationship has not been established. Thus, a two-sample Mendelian randomization (MR) study was conducted to explore the potential causal effect between IBD and CVD outcomes.
We performed a two-sample MR analysis to analyze the causal effect of the IBD on CVD outcome by using summary-level genome-wide association studies of European descent. The inverse-variance weighted (IVW) method was used as the main MR analysis, with complementary analyses of MR Egger, maximum likelihood, weighted median, penalized weighted media, simple mode, weighted mode, and MR-PRESSO methods. Multiple sensitivity analyses were used to evaluate the robustness of our results.
All -values were greater than 0.05 in the IVW method, showing no evidence of a causal association between circulating IBD and CVD. Similar results were observed by using other MR methods. No evidence of heterogeneity, pleiotropy, or outlier single-nucleotide polymorphisms was detected. Sensitivity analyses demonstrated the robustness of the results.
The findings of this study provided no evidence to support that IBD has a large effect on risk of CVD outcomes, which is in contrast to many previous observational reports. Further studies are needed to determine the potential mechanism of association identified in observational studies.
尽管流行病学研究表明炎症性肠病（IBD）与心血管疾病（CVD）结局风险之间存在正相关关系，但尚未确立确凿的因果关系。因此，开展了一项两样本孟德尔随机化（MR）研究，以探索IBD与CVD结局之间的潜在因果效应。
我们进行了两样本MR分析，通过使用欧洲血统人群的汇总水平全基因组关联研究来分析IBD对CVD结局的因果效应。采用逆方差加权（IVW）方法作为主要的MR分析方法，并对MR-Egger、最大似然、加权中位数、惩罚加权中位数、简单模式、加权模式和MR-PRESSO方法进行了补充分析。使用多种敏感性分析来评估我们结果的稳健性。
IVW方法中的所有P值均大于0.05，表明循环IBD与CVD之间没有因果关联的证据。使用其他MR方法也观察到了类似的结果。未检测到异质性、多效性或异常单核苷酸多态性的证据。敏感性分析表明结果具有稳健性。
本研究结果没有提供证据支持IBD对CVD结局风险有很大影响，这与许多先前的观察性报告相反。需要进一步研究来确定观察性研究中所确定的潜在关联机制。
