Charpin D, Kleisbauer J P, Fondarai J, Graland B, Viala A, Gouezo F
Laboratoire de Santé Publique, Faculté de Médecine, Marseille, France.
Arch Environ Health. 1988 Jan-Feb;43(1):22-7. doi: 10.1080/00039896.1988.9934369.
The influence of daily changes in sulfur dioxide (SO2) levels on the induction of respiratory symptoms was studied during the 1983-1984 winter in 450 children, aged 9 to 11 yr, living in the Gardanne coal-basin, France. In this area, SO2 originates mainly from a coal-fueled power plant. The mean SO2 level during the winter was 22 micrograms/m3 in low-pollution areas and 93 micrograms/m3 in polluted areas, with daily SO2 levels up to 356 micrograms/m3. Children completed a daily diary about respiratory symptoms. In the polluted communities only we demonstrated a significant association between daily SO2 levels (after controlling for temperature and respirable particle variations) and prevalence of upper and lower respiratory symptoms. However, in each polluted town, and for each respiratory symptom, there was no evidence for either a latency period or a delay in the effects of pollutants. Mean daily temperature was also closely correlated with upper and lower respiratory symptoms in most of the polluted and some low-pollution communities. In a second step, the prevalence of respiratory symptoms in each town was compared, during two 2-wk periods, with air pollution levels; higher prevalences were found during the pollution period. In conclusion, moderate daily changes in SO2 levels induce a significant but transient increase in the prevalence of respiratory symptoms in children.
1983 - 1984年冬季，在法国加尔丹煤盆地，对450名9至11岁儿童进行了研究，以探讨二氧化硫（SO₂）水平的每日变化对呼吸道症状诱发的影响。该地区的SO₂主要来源于一座以煤为燃料的发电厂。冬季期间，低污染地区的SO₂平均水平为22微克/立方米，污染地区为93微克/立方米，每日SO₂水平最高可达356微克/立方米。孩子们每天记录呼吸道症状。仅在污染社区，我们发现每日SO₂水平（在控制了温度和可吸入颗粒物变化之后）与上、下呼吸道症状的患病率之间存在显著关联。然而，在每个污染城镇以及每种呼吸道症状中，均未发现污染物影响存在潜伏期或延迟的证据。在大多数污染社区和一些低污染社区，日平均温度也与上、下呼吸道症状密切相关。第二步，在两个为期2周的时间段内，比较了每个城镇呼吸道症状的患病率与空气污染水平；在污染期发现患病率更高。总之，SO₂水平的适度每日变化会导致儿童呼吸道症状患病率显著但短暂地增加。
