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英国炼焦厂附近居民的死亡率。

Mortality among residents near cokeworks in Great Britain.

作者信息

Dolk H, Thakrar B, Walls P, Landon M, Grundy C, Sáez Lloret I, Wilkinson P, Elliott P

机构信息

Department of Public Health and Policy, School of Hygiene and Tropical Medicine, London, UK.

出版信息

Occup Environ Med. 1999 Jan;56(1):34-40. doi: 10.1136/oem.56.1.34.

Abstract

OBJECTIVES

To investigate whether residents near cokeworks have a higher standardised mortality than those further away, particularly from cardiovascular and respiratory causes, which may be associated with pollution from cokeworks.

METHOD

Cross sectional small area study with routinely collected postcoded mortality data and small area census statistics. Populations within 7.5 km of 22 cokeworks in Great Britain, 1981-92. Expected numbers of deaths within 2 and 7.5 km of cokeworks, and in eight distance bands up to 7.5 km of cokeworks, were calculated by indirect standardisation from national rates stratified for age and sex and a small area deprivation index, and adjusted for region. Age groups examined were all ages, 1-14, 15-64, 65-74, > or = 75. Only the 1-14 and 15-44 age groups were examined for asthma mortality.

RESULTS

There was a 3% (95% confidence interval (95% CI) 1% to 4%) excess of all deaths within 2 km of cokeworks, and a significant decline in mortality with distance from cokeworks. The excess of deaths within 2 km was slightly higher for females and elderly people, but excesses within 2 km and declines in risk with distance were significant for all adult age groups and both sexes. The size of the excess within 2 km was 5% (95% CI 3% to 7%) for cardiovascular causes, 6% (95% CI 3% to 9%) for ischaemic heart disease, and 2% (95% CI -2% to 6%) for respiratory deaths, with significant declines in risk with distance for all these causes. There was a non-significant 15% (95% CI -1% to 101%) excess in asthma mortality in the 15-44 age group. There were no significant excesses in mortality among children but 95% CIs were wide. Within 2 km of cokeworks, the estimated additional excess all cause mortality for all ages combined related to region and mainly to the greater deprivation of the population over national levels was 12%.

CONCLUSIONS

A small excess mortality near cokeworks as found in this study is plausible in the light of current evidence about the health impact of air pollution. However, in this study the effects of pollution from cokeworks, if any, are outweighed by the effects of deprivation on weighed by the effects of deprivation on mortality near cokeworks. It is not possible to confidently exclude socioeconomic confounding or biases resulting from inexact population estimation as explanations for the excess found.

摘要

目的

调查炼焦厂附近居民的标准化死亡率是否高于距离较远的居民,特别是心血管疾病和呼吸系统疾病导致的死亡率,这可能与炼焦厂污染有关。

方法

采用横断面小区域研究,收集常规编码的死亡率数据和小区域人口普查统计数据。研究对象为1981 - 1992年英国22家炼焦厂7.5公里范围内的人群。通过间接标准化方法,根据全国按年龄、性别分层的死亡率以及小区域贫困指数计算炼焦厂2公里和7.5公里范围内以及距离炼焦厂7.5公里以内8个距离区间的预期死亡人数,并对地区进行调整。研究的年龄组包括所有年龄、1 - 14岁、15 - 64岁、65 - 74岁、≥75岁。仅对1 - 14岁和15 - 44岁年龄组的哮喘死亡率进行了研究。

结果

炼焦厂2公里范围内的全因死亡人数超出3%(95%置信区间(95%CI)为1%至4%),且死亡率随与炼焦厂距离的增加而显著下降。2公里范围内女性和老年人的死亡人数超出略高,但2公里范围内的超出人数以及风险随距离的下降在所有成年年龄组和男女中均显著。2公里范围内心血管疾病导致的死亡人数超出为5%(95%CI为3%至7%),缺血性心脏病为6%(95%CI为3%至9%),呼吸系统疾病死亡为2%(95%CI为 - 2%至6%),所有这些原因导致的风险均随距离显著下降。15 - 44岁年龄组哮喘死亡率超出15%(95%CI为 - 1%至101%),无统计学意义。儿童死亡率无显著超出,但95%CI范围较宽。在炼焦厂2公里范围内,所有年龄组综合估计因地区导致的额外全因死亡人数超出,主要与人口比全国水平更贫困有关,为12%。

结论

根据目前关于空气污染对健康影响的证据,本研究中发现的炼焦厂附近少量的死亡人数超出是合理的。然而,在本研究中,炼焦厂污染的影响(如果有的话)被贫困对炼焦厂附近死亡率的影响所抵消。无法确定地排除社会经济混杂因素或因人口估计不准确导致的偏差作为所发现的超出的解释。

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