Moreno-Acosta Pablo, Romero-Rojas Alfredo, Vial Nicolas, Huertas Antonio, Acosta Jinneth, Mayorga Diana, Carrillo Schyrly, Molano Monica, Gamboa Oscar, Cotes Martha, Casadiego Camila, Vallard Alexis, Magne Nicolas
Research Group in Radiobiology Clinical, Molecular and Cellular, National Cancer Institute, Bogota, Colombia.
Research Group in Cancer Biology, National Cancer Institute, Bogota, Colombia.
Case Rep Obstet Gynecol. 2020 Jul 23;2020:6806857. doi: 10.1155/2020/6806857. eCollection 2020.
This article is a preliminary investigational study that is aimed at giving hints about the interesting biomarkers involved in the transition process from low-grade cervix lesion to invasive cervical cancer. Our study focuses on the risk factors and tumour molecular changes in one patient. First in 1986, she was diagnosed a preinvasive cervix lesion. Then, 16 years later, she was diagnosed an invasive cervical cancer. The 2002 diagnosis was a squamous cell carcinoma of the cervix, stage IIIB (FIGO), whereas in 1986, she had been diagnosed a high-grade squamous intraepithelial cervical lesion. Retrospectively, the analysis of samples of preneoplastic lesions and invasive cervical cancer confirmed the histopathological diagnoses and detected the presence of HPV type and HPV-16 variants, as well as the overexpression of proteins such as hTERT, IGF1R, IGF1R, CAIX, and GLUT1. Finally, the Arg72Pro polymorphism was detected in TP53. The role of high-risk HPV and HPV-16 variants and of hTERT, IGF1R, IGF1R, CAIX, and GLUT1 variations seemed confirmed in the development and progression of cervical cancer. As a result, analyzing the molecular changes in one and same tumour that progresses from a low-grade cervix lesion to invasive cervical cancer could provide valuable information in order to improve detection, diagnosis, and treatment in the future.
本文是一项初步的调查研究，旨在揭示与低度宫颈病变向浸润性宫颈癌转变过程相关的有趣生物标志物。我们的研究聚焦于一名患者的危险因素和肿瘤分子变化。1986年，她首次被诊断为宫颈原位病变。16年后，她被诊断为浸润性宫颈癌。2002年的诊断结果是宫颈鳞状细胞癌，III B期（国际妇产科联盟分期），而在1986年，她被诊断为高级别宫颈鳞状上皮内病变。回顾性地分析癌前病变和浸润性宫颈癌的样本，证实了组织病理学诊断，并检测到了人乳头瘤病毒（HPV）类型和HPV - 16变体的存在，以及hTERT、IGF1R、IGF1R、CAIX和GLUT1等蛋白质的过表达。最后，在TP53中检测到了Arg72Pro多态性。高危HPV和HPV - 16变体以及hTERT、IGF1R、IGF1R、CAIX和GLUT1变化在宫颈癌发生和发展中的作用似乎得到了证实。因此，分析同一肿瘤从低度宫颈病变发展为浸润性宫颈癌过程中的分子变化，可为未来改善检测、诊断和治疗提供有价值的信息。
