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复杂胫骨感染治疗中的同期清创、伊里扎洛夫重建术及游离肌皮瓣移植术

Simultaneous debridement, Ilizarov reconstruction and free muscle flaps in the management of complex tibial infection.

作者信息

Mifsud Max, Ferguson Jamie Y, Stubbs David A, Ramsden Alex J, McNally Martin A

机构信息

The Oxford Bone Infection Unit, Nuffield Orthopaedic Centre, Oxford, University Hospitals NHS Foundation Trust, Windmill Road, Oxford, OX3 7HE, UK.

出版信息

J Bone Jt Infect. 2020 Dec 22;6(3):63-72. doi: 10.5194/jbji-6-63-2020. eCollection 2020.

Abstract

Chronic bone infections often present with complex bone and soft tissue loss. Management is difficult and commonly delivered in multiple stages over many months. This study investigated the feasibility and clinical outcomes of reconstruction in one stage. Fifty-seven consecutive patients with chronic osteomyelitis ( ) or infected non-union ( ) were treated with simultaneous debridement, Ilizarov method and free muscle flap transfer. 41 patients (71.9 %) had systemic co-morbidities (Cierny-Mader group Bs hosts). Infection was confirmed with strict criteria. 48 patients (84.2 %) had segmental defects. The primary outcome was eradication of infection at final follow-up. Secondary outcomes included bone union, flap survival and complications or re-operation related to the reconstruction. Infection was eradicated in cases (96.5 %) at a mean follow-up of 36 months (range 12-146). No flap failures occurred during distraction but 6 required early anastomotic revision and 3 were not salvageable (flap failure rate 5.3 %). Bony union was achieved in (91.2 %) with the initial surgery alone. After treatment of the five un-united docking sites, all cases achieved bony union at final follow-up. Simultaneous reconstruction with Ilizarov method and free tissue transfer is safe but requires careful planning and logistic considerations. The outcomes from this study are equivalent or better than those reported after staged surgery.

摘要

慢性骨感染常伴有复杂的骨与软组织缺损。治疗困难,通常需在数月内分多个阶段进行。本研究调查了一期重建的可行性及临床疗效。连续57例慢性骨髓炎( )或感染性骨不连( )患者接受了同期清创、伊里扎洛夫技术及游离肌皮瓣转移治疗。41例患者(71.9%)伴有全身性共病(Cierny-Mader Bs型宿主)。感染依据严格标准确诊。48例患者(84.2%)存在节段性骨缺损。主要结局为末次随访时感染根除。次要结局包括骨愈合、皮瓣存活以及与重建相关的并发症或再次手术情况。平均随访36个月(范围12 - 146个月)时, 例患者(96.5%)感染得以根除。牵张过程中未发生皮瓣坏死,但6例需要早期吻合口修复,3例无法挽救(皮瓣坏死率5.3%)。仅初次手术就使 例患者(91.2%)实现了骨愈合。在处理了5个未愈合的对接部位后,所有病例在末次随访时均实现了骨愈合。伊里扎洛夫技术与游离组织转移同期重建是安全的,但需要仔细规划和后勤保障。本研究结果等同于或优于分期手术报告的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61b0/7852407/6bf4c41b2a2f/jbji-6-63-g01.jpg

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