Oxley D K
Department of Pathology, St Joseph Health Center, Kansas City, Mo.
Arch Pathol Lab Med. 1988 Apr;112(4):387-91.
This is a status report on cholesterol testing, using data from the College of American Pathologists Surveys program and Quality Assurance Service and the Lipid Research Clinics program. The clinical context for cholesterol testing is reviewed in order to develop a conceptual framework for analytic goals. Our analysis leads us to the following conclusions: First, the accuracy of cholesterol assays will be improved by using newly available reference material labeled by definitive methodology; this aspect of cholesterol testing is well monitored by proficiency testing. Tight goals for accuracy must await a consensus on the true value of test specimens. Second, long-term intralaboratory analytic variability, which is crucial in cholesterol testing, is well monitored by programs like the Quality Assurance Service, but not by proficiency testing. It is proposed that pathologists use realistic performance goals that incorporate a total error model and biologic variability.
这是一份关于胆固醇检测的现状报告，使用了美国病理学家学会调查项目、质量保证服务以及脂质研究诊所项目的数据。为了建立分析目标的概念框架，对胆固醇检测的临床背景进行了回顾。我们的分析得出以下结论：第一，使用采用权威方法标记的新可用参考物质将提高胆固醇检测的准确性；胆固醇检测的这一方面通过能力验证得到了很好的监测。准确的严格目标必须等待对测试样本真实值达成共识。第二，长期的实验室内部分析变异性在胆固醇检测中至关重要，通过质量保证服务等项目得到了很好的监测，但能力验证无法做到。建议病理学家使用包含总误差模型和生物变异性的实际性能目标。
