Lawson N S, Gilmore B F, Tholen D W
Department of Pathology, St John Hospital, Detroit, MI 48236.
Arch Pathol Lab Med. 1988 Apr;112(4):454-61.
We establish that, for the analytes aspartate aminotransferase, glucose, phosphorus, and potassium, there is significant correlation between laboratory performance as determined by College of American Pathologists-sponsored external (Surveys) and expanded internal (regional) quality control (Quality Assurance Service) programs. However, relatively low parametric and nonparametric correlation coefficients and significant departure of linear regression slopes from unity reflect major differences in the calculated parameters of absolute bias, precision, and total error obtained through internal and external quality control. Significantly better performance in both Surveys and the Quality Assurance Service was documented for laboratories participating in the College of American Pathologists Laboratory Accreditation Program. Multiple descriptors of laboratory quality, as indicated here, are superior in describing laboratory performance to proficiency testing alone. As a bridge between external and internal quality control, shared pools of quality control materials are described for use as unknown Survey challenges and subsequent distribution for regional quality control. Such programs, which can be configured to serve thousands of laboratories, could offer cost savings, better quality assurance, and improved characterization of laboratory performance by minimizing interprogram differences in control matrix and method classification and providing greater reliability of target values.
我们证实，对于天冬氨酸转氨酶、葡萄糖、磷和钾这些分析物，在美国病理学家学会主办的外部（调查）和扩展的内部（区域）质量控制（质量保证服务）计划所确定的实验室性能之间存在显著相关性。然而，相对较低的参数和非参数相关系数以及线性回归斜率与单位的显著偏差反映了通过内部和外部质量控制获得的绝对偏差、精密度和总误差计算参数的主要差异。参与美国病理学家学会实验室认可计划的实验室在调查和质量保证服务方面的表现均显著更好。如此处所示，实验室质量的多个描述符在描述实验室性能方面优于单独的能力验证。作为外部和内部质量控制之间的桥梁，描述了共享的质量控制材料池，用作未知的调查挑战，并随后用于区域质量控制。这样的计划可以配置为服务数千个实验室，通过最小化控制基质和方法分类中的计划间差异并提供更高的目标值可靠性，从而节省成本、提供更好的质量保证并改善实验室性能的特征描述。
