Maranata Gabriella Josephine, Surya Natasha Octavianti, Hasanah Aliya Nur
Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung Sumedang KM 21, 5, Jatinangor, 45363, Sumedang, Indonesia.
Drug Discovery and Drug Development Research Center, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung Sumedang KM 21,5, Jatinangor, 45363, Sumedang, Indonesia.
Heliyon. 2021 Jan 28;7(1):e05934. doi: 10.1016/j.heliyon.2021.e05934. eCollection 2021 Jan.
Molecular imprinted solid-phase extraction is the technique that uses molecular imprinted polymer as the sorbent in solid phase extraction. Molecular imprinted solid-phase extraction is effective and efficient for the extraction process and cleaning as compared with solid phase extraction (SPE) without molecular imprinted polymer. The complexity of variables in molecular imprinted solid-phase extraction arise as problems in the analysis, therefore it is necessary to optimize the extraction conditions of molecular imprinted solid-phase extraction. To achieve the sorption equilibrium and achieve the shortest time, certain parameters such as contact time, ion strength of sample, pH of sample, amount of sorbent, sample flow rate, addition of salt and buffer solution, washing solvent, elution solvent, and loading solvent need to be optimized. The selection of suitable properties and quantities of each factor greatly affect the formation of appropriate interactions between the sorbent and analytes. Percentage recovery is also influenced by formation of the appropriate bonds, sample flow rates, extraction time, salt addition, and sorbent mass. Therefore, in the future, molecular imprinted solid-phase extraction optimization has to consider and adjust various factors reviewed in this paper to form appropriate interactions between the absorbent and target molecules which have an impact on the optimal results.
分子印迹固相萃取是一种在固相萃取中使用分子印迹聚合物作为吸附剂的技术。与没有分子印迹聚合物的固相萃取（SPE）相比，分子印迹固相萃取在萃取过程和净化方面有效且高效。分子印迹固相萃取中变量的复杂性在分析中成为问题，因此有必要优化分子印迹固相萃取的萃取条件。为了达到吸附平衡并实现最短时间，需要优化某些参数，如接触时间、样品的离子强度、样品的pH值、吸附剂的量、样品流速、盐和缓冲溶液的添加、洗涤溶剂、洗脱溶剂和上样溶剂。每个因素合适的性质和数量的选择极大地影响吸附剂与分析物之间适当相互作用的形成。回收率也受到适当键的形成、样品流速、萃取时间、盐添加和吸附剂质量的影响。因此，未来分子印迹固相萃取的优化必须考虑并调整本文中综述的各种因素，以在吸附剂和目标分子之间形成适当的相互作用，这对优化结果有影响。
