Kaura Anika, Shukla Rishi, Lamyman Abigail, Almeyda Robert, Draper Mark, Martinez-Devesa Pablo, Qureishi Ali
Ear Institute, University College London, London, UK.
Department of ENT Surgery, John Radcliffe Hospital, Headley Way, Headington, Oxford, UK.
Turk Arch Otorhinolaryngol. 2020 Dec;58(4):254-267. doi: 10.5152/tao.2020.5218. Epub 2020 Dec 1.
This review examines the latest evidence for photodynamic therapy (PDT) in treating chronic rhinosinusitis. MedLine, EMBASE and TRIP Database searches were conducted using the terms: "photodynamic" or "phototherapy" or "photo" and "sinusitis" or "rhinosinusitis," date range January 2000 to May 2020. A total of 192 records were initially identified, after duplicates and exclusions, 9 full papers and 3 abstracts were included. All study types including in-vitro, animal and human studies were evaluated. Whilst there is in-vitro evidence for the efficacy of PDT's bactericidal effect on drug resistant bacteria and biofilm viability, there are few clinical studies. PDT is a promising area of research, but larger, focused studies looking at the safety, delivery, efficacy, and patient selection are required before it can be considered a viable treatment for CRS.
本综述探讨了光动力疗法（PDT）治疗慢性鼻-鼻窦炎的最新证据。使用以下检索词在医学在线数据库（MedLine）、荷兰医学文摘数据库（EMBASE）和循证医学数据库（TRIP Database）中进行检索：“光动力”或“光疗法”或“光”以及“鼻窦炎”或“鼻-鼻窦炎”，日期范围为2000年1月至2020年5月。最初共识别出192条记录，经去除重复记录和排除后，纳入了9篇全文和3篇摘要。对包括体外、动物和人体研究在内的所有研究类型进行了评估。虽然有体外证据表明PDT对耐药菌和生物膜活力具有杀菌作用，但临床研究较少。PDT是一个有前景的研究领域，但在其被视为慢性鼻-鼻窦炎的可行治疗方法之前，需要开展更大规模、针对性更强的研究，以探讨其安全性、给药方式、疗效和患者选择。
