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一名儿童因杏仁硫化而出现获得性喉软化和气管软化的罕见病例。

A Rare Presentation of Acquired Laryngomalacia and Tracheomalacia in a Child Associated with Apricot Sulfurization.

作者信息

Vehapoğlu Aysel, Çakır Erkan, Uzuner Selçuk, Çalım Ömer Faruk, Yazan Hakan

机构信息

Department of Pediatrics, Bezmialem Vakıf University School of Medicine, İstanbul, Turkey.

Department of Pediatric Pulmonology, Bezmialem Vakıf University School of Medicine, İstanbul, Turkey.

出版信息

Turk Arch Otorhinolaryngol. 2020 Dec;58(4):286-288. doi: 10.5152/tao.2020.5398. Epub 2020 Dec 1.

DOI:10.5152/tao.2020.5398
PMID:33554206
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7846308/
Abstract

Sulfur fumigation has come to replace traditional sun drying methods for drying fruits over the years around the world as it is a cheaper and faster method because of its pesticidal and anti-bacterial properties. We report the case of an 11-year-old boy with acquired severe biphasic stridor who was exposed to extremely high concentrations of sulfur dioxide (SO2) during apricot sulfurization processes with his mother. The patient's bronchoscopy revealed severe glottic and subglottic damage. Exposure to SO2 is a health risk, particularly for individuals who are sulfide-sensitive, especially in childhood. The pulmonary epithelium may be directly injured by inhaled toxic substances at various levels of the respiratory system. To the best of our knowledge, this is the first case reported of acquired airway damage associated with sulfurization in a pediatric patient without a known history of any respiratory disease or symptoms.

摘要

多年来,在世界各地,硫磺熏蒸已逐渐取代传统的日晒方法来干燥水果,因为它具有杀虫和抗菌特性,是一种更便宜、更快的方法。我们报告了一例11岁男孩的病例,该男孩在与母亲一起进行杏子硫化过程中接触到极高浓度的二氧化硫(SO₂),随后出现了严重的双相性喘鸣。患者的支气管镜检查显示声门和声门下严重受损。接触SO₂会对健康构成风险,尤其是对硫化物敏感的个体,在儿童时期尤为如此。吸入的有毒物质可能会在呼吸系统的不同层面直接损伤肺上皮。据我们所知,这是首例报道的在无任何已知呼吸系统疾病或症状病史的儿科患者中,与硫化相关的获得性气道损伤病例。

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本文引用的文献

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Sulfite-induced protein radical formation in LPS aerosol-challenged mice: Implications for sulfite sensitivity in human lung disease.亚硫酸盐诱导脂多糖气溶胶攻击小鼠的蛋白自由基形成:对人类肺部疾病中亚硫酸盐敏感性的影响。
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