过度训练的运动员和神经退行性疾病患者有什么共同点？线粒体功能障碍。
What do over-trained athletes and patients with neurodegenerative diseases have in common? Mitochondrial dysfunction.
机构信息
Faculty of Sport and Physical Education, University of Novi Sad, 21000 Novi Sad, Serbia.
Faculty of Health Sciences, University of Pécs, 7622 Pécs, Hungary.
出版信息
Exp Biol Med (Maywood). 2021 Jun;246(11):1241-1243. doi: 10.1177/1535370221990619. Epub 2021 Feb 7.
Abstract
Under pathological conditions and excessive stress, mitochondria may experience a severe and irreversible loss of function. Both strenuous exhaustive exercise and neurodegenerative disorders appear to share defects in mitochondrial function that may fiercely disrupt the integrity and homeostasis of the organelle, leading to perennial pathological substrates. Here, we overview similarities of mitochondrial dysfunction in two conditions and discuss possible areas of interdisciplinary collaboration and research translation between sports medicine and neurology.
摘要
在病理条件和过度应激下，线粒体可能会经历严重且不可逆转的功能丧失。剧烈的体力消耗性运动和神经退行性疾病似乎都存在线粒体功能缺陷，这可能会严重破坏细胞器的完整性和内稳态，导致长期存在的病理基础。在这里，我们概述了这两种情况下线粒体功能障碍的相似之处，并讨论了运动医学和神经学之间可能的跨学科合作和研究转化领域。
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Ann Neurol. 2018 Jan;83(1):115-130. doi: 10.1002/ana.25127.
6
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7
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8
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