Fraunhofer Institute for Applied Polymer Research (IAP), Potsdam-Golm, Germany.
Institute of Biotechnology, Molecular Cell Biology, Brandenburg University of Technology, Senftenberg, Germany.
Clin Hemorheol Microcirc. 2021;78(2):151-161. doi: 10.3233/CH-201096.
Within the last years a comprehensive number of scientific studies demonstrated beneficial effect of Arthropira platensis (AP) as dietary supplement due to a high content of proteins, minerals and vitamins. Positive effects like promoting the immune system, reducing inflammation and an anti-oxidant capacity are reported. In this study, the effect of an aqueous AP extract on primary human venous endothelial cells (HUVEC) was investigated. In addition, the effect of AP on HUVEC treated with a bacterial toxin (lipopolysaccharide, LPA), inducing an activation of HUVEC and cellular detachment, was analyzed. Depending on the concentration of AP extract a significantly accelerated formation of an endothelial cell monolayer was observed. Furthermore, the detachment of HUVEC after LPA addition was dramatically reduced by AP. In conclusion, the data are promising and indicatory for an application of Arthrospira platensis in the clinical field.
在过去的几年中，大量科学研究表明，由于含有丰富的蛋白质、矿物质和维生素，节旋藻（AP）作为膳食补充剂具有有益的效果。据报道，它具有促进免疫系统、减轻炎症和抗氧化能力等积极作用。在这项研究中，研究了节旋藻水提物对原代人静脉内皮细胞（HUVEC）的影响。此外，还分析了节旋藻对用细菌毒素（脂多糖，LPA）处理的 HUVEC 的影响，该毒素可激活 HUVEC 并导致细胞脱落。根据节旋藻提取物的浓度，观察到内皮细胞单层的形成明显加快。此外，节旋藻显著减少了 LPA 加药后 HUVEC 的脱落。总之，这些数据有希望并表明可以将节旋藻应用于临床领域。
