• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

（螺旋藻）递送方法的改进可提高治疗效果。

Advances in delivery methods of (spirulina) for enhanced therapeutic outcomes.

机构信息

School of Pharmacy, Faculty of Science and Engineering, University of Nottingham Malaysia, Jalan Broga, Semenyih, Malaysia.

Department of Pharmaceutical Sciences, College of Pharmacy, QU Health, Qatar University, Doha, Qatar.

出版信息

Bioengineered. 2022 Jun;13(6):14681-14718. doi: 10.1080/21655979.2022.2100863.

DOI:10.1080/21655979.2022.2100863
PMID:35946342
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9373759/
Abstract

() aqueous extract has massive amounts of natural products that can be used as future drugs, such as C-phycocyanin, allophycocyanin, etc. This extract was chosen because of its high adaptability, which reflects its resolute genetic composition. The proactive roles of cyanobacteria, particularly in the medical field, have been discussed in this review, including the history, previous food and drug administration (FDA) reports, health benefits and the various dose-dependent therapeutic functions that possesses, including its role in fighting against lethal diseases such as cancer, SARS-CoV-2/COVID-19, etc. However, the remedy will not present its maximal effect without the proper delivery to the targeted place for deposition. The goal of this research is to maximize the bioavailability and delivery efficiency of constituents through selected sites for effective therapeutic outcomes. The solutions reviewed are mainly on parenteral and tablet formulations. Moreover, suggested enteric polymers were discussed with minor composition variations applied for better storage in high humid countries alongside minor variations in the polymer design were suggested to enhance the premature release hindrance of basic drugs in low pH environments. In addition, it will open doors for research in delivering active pharmaceutical ingredients (APIs) in femtoscale with the use of various existing and new formulations. SDGs; , IL-4; , HDL; , LDL; , VLDL; , C-PC; , APC; , PE; , COX-2; , RCTs; , TNF-α; , γ-LFA; , PGs; , PUFAs: , NK-cell; , FDA; , GRAS; , SD; , API; , DW; , IM; , IV; , ID; , SC; , AERs; , DSI-EC; , cGMP; , Spirulina sp.; species, , Tecuitlatl; , CRC; , HDI; , Tf; , TfR; , FR; , CPP; , SUV; , LUV; , GUV; , MLV; , COVID-19; , PEGylated; , PEG; , OSCEs; , GI; , CAP; , HPMCP, , SR; , DR; , Poly(MA-EA); -DR L-30 D-55; , MW; , T; , SN; , EPR; , VEGF; , RGD; , VCAM-1; , P; , PES; , pH; , ζ-potential; , NTA; , PB; , DLS; , AFM; , Log P; , MR; , tPSA; , C log P; , CMR; , Log S; , pka; , DDAB; , DOPE; , GDP; , RES; , PKU; , MS; , SLE; , NASA; , DOX; , ADRs; , SVM; , MDA; , TBARS; , CRP; , CK; , LDH; , T2D; , PCB; , PBP; , PEB; , DPP-4; , MTT; , IL-2; , IL-6; , PRISMA; , STATA; , HepG2; , HCT116; , Kasumi-1; , K562; , Se-PC; , MCF-7; , A375; , RAS; , IQP; , VEP; , M; , PL; , BMI; , IC; , LD; , PC12 Adh; , RNS; , Hb1Ac; .

摘要

藻蓝蛋白、别藻蓝蛋白等天然产物的大量存在，使（）水提取物成为未来药物的潜在来源。选择这种提取物是因为它具有很强的适应性，这反映了其坚决的遗传组成。本文综述了蓝细菌的积极作用，特别是在医学领域的作用，包括历史、以前的食品和药物管理局（FDA）报告、健康益处以及它所具有的各种剂量依赖性治疗功能，包括在对抗致命疾病如癌症、SARS-CoV-2/COVID-19 等方面的作用。然而，如果没有将药物有效递送到靶向部位，这种药物将无法发挥其最大效果。本研究的目的是通过选择合适的部位来最大化 成分的生物利用度和递送效率，以实现有效的治疗效果。综述的解决方案主要是针对肠外和片剂制剂。此外，还讨论了建议使用的肠溶聚合物，以实现更好的储存，在高湿度国家可进行少量成分变化，同时建议对聚合物设计进行微小变化，以增强在低 pH 环境中基本药物的早期释放障碍。此外，它将为使用各种现有和新制剂在飞秒尺度上输送活性药物成分（APIs）的研究打开大门。可持续发展目标；白细胞介素-4；高密度脂蛋白；低密度脂蛋白；极低密度脂蛋白；藻蓝蛋白；藻蓝蛋白；精氨酸；环氧化酶-2；随机对照试验；肿瘤坏死因子-α；γ-分泌酶；前列腺素；多不饱和脂肪酸：自然杀伤细胞；FDA；一般公认安全；标准差；API；稀释剂；肌内；静脉；皮内；皮下；不良反应事件；直接标靶给药系统；良好生产规范；螺旋藻属；物种；特库蒂特兰；结直肠癌；高密度脂蛋白；转铁蛋白；转铁蛋白受体；转铁蛋白；乳铁蛋白；转铁蛋白受体；细胞穿透肽；SUV；LUV；GUV；MLV；COVID-19；聚乙二醇化；聚乙二醇；客观结构化临床考试；胃肠道；卡泊芬净；羟丙甲纤维素，；控释；迟释；聚（甲基丙烯酸乙酯-衣康酸）-DR L-30 D-55；分子量；温度；盐；电子顺磁共振；血管内皮生长因子；精氨酸-甘氨酸-天冬氨酸；血管细胞黏附分子-1；血小板；聚醚砜；pH 值；ζ-电位；氮三乙酸；聚丁二烯；动态光散射；原子力显微镜；Log P；磁共振成像；总表面积；C log P；C 代谢率；Log S；pka；十六烷基三甲基溴化铵；二油酰基磷脂酰乙醇胺；鸟苷二磷酸；Resiquimod；苯丁酸氮芥；多发性骨髓瘤；系统性红斑狼疮；美国国家航空航天局；阿霉素；药物不良反应；支持向量机；丙二醛；三丁酸甘油酯；C 反应蛋白；肌酸激酶；乳酸脱氢酶；2 型糖尿病；多氯联苯；肽基脯氨酰顺反异构酶；四甲基偶氮唑盐；白细胞介素-2；白细胞介素-6；PRISMA；STATA；HepG2；HCT116；Kasumi-1；K562；硒代藻蓝蛋白；乳腺癌细胞；A375；RAS；内量子效率；外量子效率；最小二乘法；方差分析；身体质量指数；置信区间；低密度脂蛋白；PC12 Adh；随机噪声；糖化血红蛋白。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/879e/9373759/0dbe3df4e8f7/KBIE_A_2100863_F0013_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/879e/9373759/24896be70697/KBIE_A_2100863_UF0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/879e/9373759/c41b80ba242e/KBIE_A_2100863_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/879e/9373759/b4d52a027994/KBIE_A_2100863_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/879e/9373759/3f8f8834bc92/KBIE_A_2100863_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/879e/9373759/b8e135c3cb94/KBIE_A_2100863_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/879e/9373759/773c6886cb6d/KBIE_A_2100863_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/879e/9373759/58bf2b30a853/KBIE_A_2100863_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/879e/9373759/a4bad7a2d6f9/KBIE_A_2100863_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/879e/9373759/4a2f4cd181f5/KBIE_A_2100863_F0008_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/879e/9373759/449434fa9478/KBIE_A_2100863_F0009_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/879e/9373759/6052b0fd86f9/KBIE_A_2100863_F0010_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/879e/9373759/079347829b71/KBIE_A_2100863_F0011_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/879e/9373759/f63d55e63c8a/KBIE_A_2100863_F0012_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/879e/9373759/0dbe3df4e8f7/KBIE_A_2100863_F0013_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/879e/9373759/24896be70697/KBIE_A_2100863_UF0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/879e/9373759/c41b80ba242e/KBIE_A_2100863_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/879e/9373759/b4d52a027994/KBIE_A_2100863_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/879e/9373759/3f8f8834bc92/KBIE_A_2100863_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/879e/9373759/b8e135c3cb94/KBIE_A_2100863_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/879e/9373759/773c6886cb6d/KBIE_A_2100863_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/879e/9373759/58bf2b30a853/KBIE_A_2100863_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/879e/9373759/a4bad7a2d6f9/KBIE_A_2100863_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/879e/9373759/4a2f4cd181f5/KBIE_A_2100863_F0008_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/879e/9373759/449434fa9478/KBIE_A_2100863_F0009_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/879e/9373759/6052b0fd86f9/KBIE_A_2100863_F0010_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/879e/9373759/079347829b71/KBIE_A_2100863_F0011_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/879e/9373759/f63d55e63c8a/KBIE_A_2100863_F0012_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/879e/9373759/0dbe3df4e8f7/KBIE_A_2100863_F0013_OC.jpg

相似文献

1
Advances in delivery methods of (spirulina) for enhanced therapeutic outcomes.（螺旋藻）递送方法的改进可提高治疗效果。
Bioengineered. 2022 Jun;13(6):14681-14718. doi: 10.1080/21655979.2022.2100863.
2
Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.在流行地区，服用抗叶酸抗疟药物的人群中，叶酸补充剂与疟疾易感性和严重程度的关系。
Cochrane Database Syst Rev. 2022 Feb 1;2(2022):CD014217. doi: 10.1002/14651858.CD014217.
3
Phycobiliproteins from (Spirulina): A New Source of Peptides with Dipeptidyl Peptidase-IV Inhibitory Activity.藻蓝蛋白（螺旋藻）：一种具有二肽基肽酶-IV 抑制活性的新型肽类来源。
Nutrients. 2020 Mar 18;12(3):794. doi: 10.3390/nu12030794.
4
Optimization Growth of Spirulina (Arthrospira) Platensis in Photobioreactor Under Varied Nitrogen Concentration for Maximized Biomass, Carotenoids and Lipid Contents.优化不同氮浓度下光生物反应器中螺旋藻（蓝藻）的生长，以最大化生物量、类胡萝卜素和脂质含量。
Recent Pat Food Nutr Agric. 2020;11(1):40-48. doi: 10.2174/2212798410666181227125229.
5
Nutraceutical Features of the Phycobiliprotein C-Phycocyanin: Evidence from ().藻胆蛋白 C-藻蓝蛋白的营养特性：来自（）的证据。
Nutrients. 2024 Jun 3;16(11):1752. doi: 10.3390/nu16111752.
6
Nanoparticles design considerations to co-deliver nucleic acids and anti-cancer drugs for chemoresistance reversal.用于逆转化疗耐药性的核酸和抗癌药物共递送的纳米颗粒设计考量
Int J Pharm X. 2022 Sep 6;4:100126. doi: 10.1016/j.ijpx.2022.100126. eCollection 2022 Dec.
7
[ phycocyanins: a perspective for use in foods for special dietary uses (brief review)].[藻蓝蛋白：用于特殊膳食用食品的前景（简要综述）]
Vopr Pitan. 2022;91(6):30-36. doi: 10.33029/0042-8833-2022-91-6-30-36. Epub 2022 Oct 10.
8
[Modified method for obtaining phycocyanine concentrate of biomass].[获取生物质藻蓝蛋白浓缩物的改良方法]
Vopr Pitan. 2023;92(5):110-116. doi: 10.33029/0042-8833-2023-92-5-110-116. Epub 2023 Sep 26.
9
[: antioxidant, hypoglycemic and hypolipidemic effects and (brief review)].[：抗氧化、降血糖和降血脂作用及（简要综述）]
Vopr Pitan. 2022;91(4):19-25. doi: 10.33029/0042-8833-2022-91-4-19-25. Epub 2022 Jul 1.
10
Time-temperature-resolved functional and structural changes of phycocyanin extracted from Arthrospira platensis/Spirulina.从节旋藻/螺旋藻中提取的藻蓝蛋白的时间-温度分辨功能和结构变化。
Food Chem. 2020 Jun 30;316:126374. doi: 10.1016/j.foodchem.2020.126374. Epub 2020 Feb 6.

引用本文的文献

1
Protective effects of Spirulina platensis and phycocyanin on sperm quality, DNA integrity, and testicular tissue following oxidative stress in rats: An experimental study.钝顶螺旋藻和藻蓝蛋白对大鼠氧化应激后精子质量、DNA完整性及睾丸组织的保护作用：一项实验研究。
Int J Reprod Biomed. 2025 Aug 27;23(7):559-568. doi: 10.18502/ijrm.v23i7.19485. eCollection 2025 Jul.
2
Co-administration of Spirulina and L-carnitine preserves ovarian reserve in a rat model of premature ovarian insufficiency via SIRT1 regulation of oxidative stress, inflammation, and apoptosis.螺旋藻与左旋肉碱联合给药通过SIRT1对氧化应激、炎症和细胞凋亡的调节作用，在大鼠卵巢早衰模型中保护卵巢储备功能。
Sci Rep. 2025 Sep 15;15(1):32527. doi: 10.1038/s41598-025-11143-2.
3

本文引用的文献

1
Sensor Network for Continuous Tablet Manufacturing.用于连续片剂制造的传感器网络
Int Symp Process Syst Eng. 2018;44:2149-2154. doi: 10.1016/b978-0-444-64241-7.50353-0.
2
A review on potential of natural products in the management of COVID-19.天然产物在新冠病毒疾病管理中的潜力综述。
RSC Adv. 2021 May 12;11(27):16711-16735. doi: 10.1039/d1ra00644d. eCollection 2021 Apr 30.
3
Blood cell-derived extracellular vesicles: diagnostic biomarkers and smart delivery systems.血细胞衍生的细胞外囊泡：诊断生物标志物和智能递药系统。
Spirulina platensis and Chlorella vulgaris in poultry nutrition - a review of current research and potential opportunities.钝顶螺旋藻和小球藻在家禽营养中的应用——当前研究及潜在机遇综述
Poult Sci. 2025 Jun 18;104(9):105456. doi: 10.1016/j.psj.2025.105456.
4
Microalgae and exercise: from molecular mechanisms and brain health to clinical perspectives in the context of 3P medicine.微藻与运动：从分子机制、脑健康到3P医学背景下的临床视角
EPMA J. 2025 Mar 26;16(2):351-386. doi: 10.1007/s13167-025-00405-8. eCollection 2025 Jun.
5
Unveiling the pharmacological mechanisms of Spirulina platensis in rheumatoid arthritis rats through the integration of serum metabolomics, pathways analysis, and experimental validation.通过血清代谢组学、通路分析和实验验证相结合揭示钝顶螺旋藻在类风湿性关节炎大鼠中的药理机制。
Naunyn Schmiedebergs Arch Pharmacol. 2025 May 7. doi: 10.1007/s00210-025-04191-y.
6
Impact of nutrient deficiency and harvesting strategy on biomass and phycocyanin production in cultures.营养缺乏和收获策略对培养物中生物量和藻蓝蛋白产量的影响。
Front Bioeng Biotechnol. 2025 Mar 24;13:1546801. doi: 10.3389/fbioe.2025.1546801. eCollection 2025.
7
Antioxidant Capacity and Thermal Stability of Extract Encapsulated in Starch Sodium Octenyl Succinate with Freeze-, Spray-, and Nanospray-Drying.辛烯基琥珀酸淀粉钠包封提取物的抗氧化能力及热稳定性：冷冻干燥、喷雾干燥和纳米喷雾干燥法
Molecules. 2025 Mar 13;30(6):1303. doi: 10.3390/molecules30061303.
8
Evidencing nickel biosorption capacity of cyanobacteria Chroococcidiopsis sp.: potential metallo-protective agents.证明蓝藻色球藻属的镍生物吸附能力：潜在的金属保护剂。
BMC Chem. 2025 Mar 5;19(1):59. doi: 10.1186/s13065-025-01393-6.
9
Noninvasive Assessment of Vascular Endothelial Growth Factor and Prognosis in Gastric Cancer Through Radiomic Features.通过影像组学特征对胃癌血管内皮生长因子及预后进行无创评估
Clin Transl Gastroenterol. 2025 Mar 1;16(3):e00802. doi: 10.14309/ctg.0000000000000802.
10
Bioactive compounds and in vitro biological properties of Arthrospira platensis and Athrospira maxima: a comparative study.钝顶螺旋藻和极大螺旋藻的生物活性化合物和体外生物学特性：比较研究。
Sci Rep. 2024 Oct 11;14(1):23786. doi: 10.1038/s41598-024-74492-4.
Bioengineered. 2021 Dec;12(1):7929-7940. doi: 10.1080/21655979.2021.1982320.
4
Isolation, Purification, Characterization, and Immunomodulatory Activity Analysis of α-Glucans from .来自……的α-葡聚糖的分离、纯化、表征及免疫调节活性分析
ACS Omega. 2021 Aug 12;6(33):21384-21394. doi: 10.1021/acsomega.1c02175. eCollection 2021 Aug 24.
5
Nutraceuticals in the Management of Dyslipidemia: Which, When, and for Whom? Could Nutraceuticals Help Low-Risk Individuals with Non-optimal Lipid Levels?营养保健品在血脂异常管理中的应用：何时、何地、何人适用？营养保健品能否帮助血脂水平非最佳的低危个体？
Curr Atheroscler Rep. 2021 Aug 4;23(10):57. doi: 10.1007/s11883-021-00955-y.
6
The effect of spirulina on type 2 diabetes: a systematic review and meta-analysis.螺旋藻对2型糖尿病的影响：一项系统评价和荟萃分析。
J Diabetes Metab Disord. 2021 Mar 2;20(1):883-892. doi: 10.1007/s40200-021-00760-z. eCollection 2021 Jun.
7
Phycobilins as Potent Food Bioactive Broad-Spectrum Inhibitors Against Proteases of SARS-CoV-2 and Other Coronaviruses: A Preliminary Study.藻胆素作为针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）和其他冠状病毒蛋白酶的强效食品生物活性广谱抑制剂：一项初步研究。
Front Microbiol. 2021 Jun 10;12:645713. doi: 10.3389/fmicb.2021.645713. eCollection 2021.
8
Correction to: Docking and toxicity assessment of compounds as potential antiviral agents against SARS-CoV-2.对《作为抗SARS-CoV-2潜在抗病毒剂的化合物的对接与毒性评估》的更正
J Appl Phycol. 2021;33(3):1603-1604. doi: 10.1007/s10811-021-02476-2. Epub 2021 May 10.
9
Spirulina supplementation and oxidative stress and pro-inflammatory biomarkers: A systematic review and meta-analysis of controlled clinical trials.螺旋藻补充剂与氧化应激和促炎生物标志物：对照临床试验的系统评价和荟萃分析。
Clin Exp Pharmacol Physiol. 2021 Aug;48(8):1059-1069. doi: 10.1111/1440-1681.13510. Epub 2021 May 24.
10
Docking and toxicity assessment of compounds as potential antiviral agents against SARS-CoV-2.作为抗SARS-CoV-2潜在抗病毒药物的化合物对接及毒性评估
J Appl Phycol. 2021;33(3):1579-1602. doi: 10.1007/s10811-021-02372-9. Epub 2021 Mar 20.