University College London, Department of Behavioral Science and Health, London, UK.
J Alzheimers Dis. 2021;80(2):555-565. doi: 10.3233/JAD-200952.
Studies have suggested that mentally stimulating activities and socially engaged lifestyles may reduce dementia risk; however, it is unclear which activities are more beneficial.
We investigated intellectual and social leisure activities in relation to dementia incidence and explored the modifying role of sex and marital status in these associations.
The sample was comprised of 8,030 participants aged 50+ from the English Longitudinal Study of Ageing, who joined at wave 1 (2002-2003), or waves 3 (2006-2007), or 4 (2008-2009). The end of the study period was wave 8 (2016-2017). Subdistribution hazard models investigated the role of leisure activities grouped into intellectual and social domains in relation to dementia while accounting for the risk of death. Subsequent analyses were conducted with individual leisure activities.
During the study period of up to 15 years, 412 participants developed dementia, and 2,192 died. We found that increased engagement in the intellectual activities' domain was associated with a decreased dementia incidence (SHR 0.85, 95% CI 0.76-0.96, p = 0.007), independent of the risk of death in married individuals, but not in those who were single, divorced, or widowed. Individual analyses for each leisure activity showed independent associations for reading newspapers in females (SHR 0.65, 95% CI 0.49-0.84, p = 0.001), mobile phone usage in males (SHR 0.61, 95% CI 0.45-0.84, p = 0.002), and having hobbies for married individuals (SHR 0.70, 95% CI 0.51-0.95, p = 0.02).
We found that intellectual leisure activities contribute to lower dementia risk in a representative population of English adults, suggesting intervention opportunities.
研究表明,刺激心智的活动和社交活跃的生活方式可能降低痴呆症风险;然而,尚不清楚哪些活动更有益。
我们调查了智力和社会休闲活动与痴呆症发病的关系,并探讨了性别和婚姻状况在这些关联中的调节作用。
该样本由参加英国老龄化纵向研究的 8030 名 50 岁以上的参与者组成,他们在第 1 波(2002-2003 年)、第 3 波(2006-2007 年)或第 4 波(2008-2009 年)加入研究。研究结束时间为第 8 波(2016-2017 年)。亚分布风险模型调查了智力和社会领域的休闲活动分组与痴呆症之间的关系,同时考虑了死亡风险。随后的分析是针对个体休闲活动进行的。
在长达 15 年的研究期间,412 名参与者患上了痴呆症,2192 人死亡。我们发现,智力活动领域的参与度增加与痴呆症发病率降低相关(SHR 0.85,95%CI 0.76-0.96,p=0.007),这与已婚人群的死亡风险无关,但与单身、离婚或丧偶人群无关。对每种休闲活动的个体分析表明,女性阅读报纸(SHR 0.65,95%CI 0.49-0.84,p=0.001)、男性使用手机(SHR 0.61,95%CI 0.45-0.84,p=0.002)和已婚人群有业余爱好(SHR 0.70,95%CI 0.51-0.95,p=0.02)存在独立关联。
我们发现,智力休闲活动有助于降低英国成年人群代表性人群的痴呆症风险,提示存在干预机会。