Kon' I Ia, Gorgoshidze L Sh, Vasil'eva O N, Kulakova S N
Biokhimiia. 1986 Jan;51(1):70-6.
The effect of alimentary vitamin A deficiency on some parameters of lipid peroxidation (LPO) in young rats was studied. It was found that under vitamin A deficiency the content of diene conjugates in liver homogenates and microsomes diminishes, whereas that of malonic aldehyde in small intestinal mucosa, liver and testis homogenates is unaffected. However, the malonic aldehyde production in liver homogenates and microsomes decreases after 60 min incubation at 37 degrees C without addition of prooxidants. At the same time, enzymatic NADPH-dependent and nonenzymatic ascorbate-dependent LPO in liver microsomes of vitamin A-deficient rats does not change significantly. The decrease of LPO intensity in vitamin A-deficient animals may be due to the reduced content in liver microsomes of the main LPO substrates, i.e., arachidonic and linoleic acids, as well as to the decrease of cytochrome P-450 level in rat liver.
研究了膳食维生素A缺乏对幼鼠脂质过氧化（LPO）某些参数的影响。结果发现，在维生素A缺乏的情况下，肝匀浆和微粒体中二烯共轭物的含量减少，而小肠黏膜、肝和睾丸匀浆中丙二醛的含量未受影响。然而，在37℃孵育60分钟且不添加促氧化剂后，肝匀浆和微粒体中丙二醛的生成减少。同时，维生素A缺乏大鼠肝微粒体中依赖酶的NADPH和依赖非酶的抗坏血酸的LPO没有显著变化。维生素A缺乏动物中LPO强度的降低可能是由于肝微粒体中主要LPO底物即花生四烯酸和亚油酸的含量减少，以及大鼠肝脏中细胞色素P - 450水平的降低。
