Suppr超能文献

白质纤维束的电突触耦合调节轴突传输延迟。

Ephaptic coupling in white matter fibre bundles modulates axonal transmission delays.

机构信息

Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

Center for Brain and Cognition, Computational Neuroscience Group, Department of Information and Communication Technologies, Universitat Pompeu Fabra, Barcelona, Spain.

出版信息

PLoS Comput Biol. 2021 Feb 8;17(2):e1007858. doi: 10.1371/journal.pcbi.1007858. eCollection 2021 Feb.

Abstract

Axonal connections are widely regarded as faithful transmitters of neuronal signals with fixed delays. The reasoning behind this is that extracellular potentials caused by spikes travelling along axons are too small to have an effect on other axons. Here we devise a computational framework that allows us to study the effect of extracellular potentials generated by spike volleys in axonal fibre bundles on axonal transmission delays. We demonstrate that, although the extracellular potentials generated by single spikes are of the order of microvolts, the collective extracellular potential generated by spike volleys can reach several millivolts. As a consequence, the resulting depolarisation of the axonal membranes increases the velocity of spikes, and therefore reduces axonal delays between brain areas. Driving a neural mass model with such spike volleys, we further demonstrate that only ephaptic coupling can explain the reduction of stimulus latencies with increased stimulus intensities, as observed in many psychological experiments.

摘要

轴突连接被广泛认为是神经元信号的忠实传递者,具有固定的延迟。这样认为的原因是,沿着轴突传播的尖峰引起的细胞外电势太小,不会对其他轴突产生影响。在这里,我们设计了一个计算框架,允许我们研究由轴突纤维束中尖峰爆发产生的细胞外电势对轴突传输延迟的影响。我们证明,尽管单个尖峰产生的细胞外电势处于微伏量级,但尖峰爆发产生的集体细胞外电势可以达到几毫伏。因此,轴突膜的去极化增加了尖峰的速度,从而减少了大脑区域之间的轴突延迟。用这样的尖峰爆发驱动神经质量模型,我们进一步证明,只有电突触耦合才能解释在许多心理实验中观察到的随着刺激强度增加而刺激潜伏期缩短的现象。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2364/7895385/2f57a9915119/pcbi.1007858.g001.jpg

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验