Kumar Shashank, Prajapati Kumari Sunita, Singh Atul Kumar, Kushwaha Prem Prakash, Shuaib Mohd, Gupta Sanjay
Department of Biochemistry, Drug Discovery and Therapeutic Laboratory, Central University of Punjab, Bathinda, 151401, India.
Department of Biochemistry, Drug Discovery and Therapeutic Laboratory, Central University of Punjab, Bathinda, 151401, India.
Cancer Lett. 2021 Apr 28;504:15-22. doi: 10.1016/j.canlet.2020.11.039. Epub 2021 Feb 6.
The human genome transcribe an array of RNAs that do not encode proteins and may act as mediators in the regulation of gene expression. Long non-coding RNAs (lncRNAs) are a group of non-coding RNAs consisting of more than 200 nucleotides of RNA transcripts that play important role in tumor development. Numerous lncRNAs have been characterized as functional transcripts associated with several biological processes and pathologic stages. Although the biological function and molecular mechanisms of lncRNAs remains to be explored, recent studies demonstrate aberrant expression of several lncRNAs linked with various human cancers. The present review summarizes the current knowledge of lncRNA expression patterns and mechanisms that contribute to carcinogenesis. In particular, we focus on lncRNAs regulating androgen receptor signaling pathways in prostate and breast cancer subtype having prognostic and therapeutic implications.
人类基因组转录出一系列不编码蛋白质的RNA，它们可能在基因表达调控中起介导作用。长链非编码RNA（lncRNA）是一组由超过200个核苷酸的RNA转录本组成的非编码RNA，在肿瘤发生发展中发挥重要作用。许多lncRNA已被鉴定为与多种生物学过程和病理阶段相关的功能性转录本。尽管lncRNA的生物学功能和分子机制仍有待探索，但最近的研究表明，几种lncRNA的异常表达与多种人类癌症有关。本综述总结了目前关于lncRNA表达模式及其在致癌作用中机制的认识。特别是，我们重点关注在前列腺癌和乳腺癌亚型中调节雄激素受体信号通路的lncRNA，它们具有预后和治疗意义。
