Coccaro Emil F, Keedy Sarah, Lee Royce, Phan K Luan
Department of Psychiatry and Behavioral Health, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.
J Psychiatr Res. 2021 Apr;136:47-53. doi: 10.1016/j.jpsychires.2021.01.015. Epub 2021 Jan 19.
Social-emotional information processing (SEIP) is critical for appropriate human interaction. It is composed of processes that underlie how we behave towards others, especially in response to adverse social threat. We conducted a study in 26 healthy participants who completed a validated Video-SEIP (V-SEIP) task in the fMRI scanning environment. The V-SEIP phases studied included encoding (ENC) of socially relevant information, hostile attribution (HA) of motive, and the negative emotional response (NER) the participant would have in the context of the video vignettes. The ENC phase was associated with activation of amygdala, left ventrolateral prefrontal cortex, right middle temporal gyrus, and visual cortex, the HA phase associated with activation of several brain regions including frontal and temporal cortex as well as basal ganglia and cerebellum, while the NER phase was associated with activation in the midbrain with regions involving the periaqueductal gray, basal ganglia, and the cerebellum. We suggest that this V-SEIP task represents a novel neuro-biomarker for the study of SEIP and that it can be extended for use in a number of psychiatric conditions in which anger, irritability, and impulsive aggressive are prominent features.
社会情感信息处理（SEIP）对于恰当的人际互动至关重要。它由一些过程组成，这些过程构成了我们如何对待他人的基础，尤其是在应对不利的社会威胁时。我们对26名健康参与者进行了一项研究，他们在功能磁共振成像（fMRI）扫描环境中完成了一项经过验证的视频社会情感信息处理（V-SEIP）任务。所研究的V-SEIP阶段包括社会相关信息的编码（ENC）、动机的敌意归因（HA）以及参与者在视频短片情境中会产生的负面情绪反应（NER）。ENC阶段与杏仁核、左侧腹外侧前额叶皮层、右侧颞中回和视觉皮层的激活相关，HA阶段与包括额叶和颞叶皮层以及基底神经节和小脑在内的多个脑区的激活相关，而NER阶段与中脑涉及导水管周围灰质、基底神经节和小脑的区域的激活相关。我们认为，这项V-SEIP任务代表了一种用于研究SEIP的新型神经生物标志物，并且它可以扩展用于许多以愤怒、易怒和冲动攻击性为突出特征的精神疾病。
